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Michelle McGuire Professor

Washington State University

The Human Milk Microbiome – A New Twist in Infant Nutrition

Michelle McGuire Professor

演讲题目:The Human Milk Microbiome – A New Twist in Infant Nutrition

Washington State University

美国华盛顿州立大学教授、国际营养学专家

她的主要研究领域为母乳喂养期间的母婴健康,研究涉及多种营养素,例如微量元素、脂质、脂肪酸、激素,还有母乳微生物。

她还长期从事产后母乳喂养期间停经及乳腺炎调节的研究,并致力于科普相关知识。

最近,她与爱达荷大学的Mark McGuire教授共同完成的国际队列INSPIRE研究揭示,母乳成分并非一成不变,而会随着人类进化、当地文化和环境的变化而调整至最适合婴儿的状态。

人们通常认为,母乳和配方奶粉喂养的婴儿,其肠道菌群不同,是因为母乳和配方奶粉的成分不同,例如,母乳中含有不易消化的寡糖。然而,她的研究结果显示,母乳中含有种类繁多的细菌。因此她推测,除了寡糖和其他成分,母乳微生物本身也会影响婴儿肠道菌群。

下一代测序结果显示,无论母乳由何处采集,含量最多的微生物通常都是葡萄球菌、链球菌和假单胞菌。其他微生物的含量差异可能来源于母乳收集方式、DNA提取扩增测序等方面。

Dr. McGuire, an internationally recognized human nutritionist and Professor at Washington State University, conducts research related to maternal and infant health – particularly during the period of breastfeeding. Her research has spanned a variety of nutrients and topics including micronutrients, lipids, fatty acids, hormones, and most recently microbes in human milk. She also has a long-standing interest in understanding and elucidating the physiologic mechanisms regulating duration of postpartum anovulation during breastfeeding as well as mammary inflammation (mastitis) . In collaboration with her husband, Dr. Mark McGuire, her research has taken her around the world and connected her with colleagues in a variety of disciplines including anthropology, microbiology, immunology, and epidemiology. Their recently completed, large, international, cohort study (INSPIRE, What’s Normal?) has convincingly shown that human milk composition is not a one-size-fits-all construct and may have been shaped by evolutionary selection, culture, and environment to optimally nourish infants living in a particular location and perhaps even household. Dr. McGuire is also a seasoned science communicator and has coauthored 2 college-level, nutrition textbooks: Nutritional Sciences: From Fundamentals to Foods (in its 3rd edition) and NUTR (in its 2nd edition). She has also served as National Spokesperson and executive board member for the American Society for Nutrition and executive board member and secretary/treasurer for the International Society for Research in Human Milk and Lactation. She has, for over 2 decades, taught introductory nutrition to a large-enrollment class (up to 500 students) and science communications at Washington State University. Dr. McGuire lives in Moscow, Idaho with her husband. When she isn’t engaged in teaching and research, Shelley enjoys cooking, running, yoga, gardening, and traveling (and eating) with her family.


Selected Publications:


First Autor and Corresponding Author:


1. McGuire MK, McGuire MA. Got bacteria? The astounding, yet not-so-surprising, microbiome of human milk. Curr Opin Biotechnol. 2017 Apr;44:63-68. doi: 10.1016/j.copbio.2016.11.013. Epub 2016 Dec 8. ( IF 9.294 )


2. McGuire MK, Meehan CL, McGuire MA, Williams JE, Foster J, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Kvist LJ, Otoo GE, Brooker SL, Price WJ, Shafii B, Placek C, Lackey KA, Robertson B, Manzano S, Ruíz L, Rodríguez JM, Pareja RG, Bode L. What's normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographicallyAm J Clin Nutr. 2017 May;105(5):1086-1100. doi: 10.3945/ajcn.116.139980. Epub 2017 Mar 29. ( IF 6.926 )


3. McGuire MK, McGuire MA, Price WJ, Shafii B, Carrothers JM, Lackey KA, Goldstein DA, Jensen PK, Vicini JL. Glyphosate and aminomethylphosphonic acid are not detectable in human milk. Am J Clin Nutr. 2016 May;103(5):1285-90. doi: 10.3945/ajcn.115.126854. Epub 2016 Mar 30. ( IF 6.926 )


4. McGuire MK, McGuire MA. Human milk: mother nature's prototypical probiotic food?Adv Nutr. 2015 Jan 15;6(1):112-23. doi: 10.3945/an.114.007435. Print 2015 Jan. ( IF 5.233 )


5. Bode L, McGuire M, Rodriguez JM, Geddes DT, Hassiotou F, Hartmann PE, McGuire MK. It’s alive: microbes and cells in human milk and their potential benefits to mother and infant.Adv Nutr. 2014 Sep;5(5):571-3. ( IF 5.233 )


Others:


2017  1 in Frontiers in Immunology ( IF 6.429 )


ClinicalTrials:


NCT02670278

Evolutionary and Sociocultural Aspects of Human Milk Composition

https://clinicaltrials.gov/ct2/show/NCT02670278?term=Michelle+McGuire&rank=1

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