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2019-03-29至2019-03-30 上海
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张晨虹 副研究员

上海交大生命科学技术学院

张晨虹 副研究员

上海交大生命科学技术学院

教育经历: 
2007年至2011年:博士,上海交通大学,生命科学技术学院,微生物代谢国家重点实验室, 2011年3月授予微生物学博士学位。(学位论文被评为2012年上海市研究生优秀成果(学位论文)) 
2005年至2007年:硕士同等教育,上海交通大学,生命科学技术学院,微生物代谢国家重点实验室 
2001年至2005年:大学本科,生物技术专业(基地班),上海交通大学,生命科学技术学院,。 

 

工作经历: 
2013年10月至今:助理研究员,上海交通大学生命科学技术学院 
2011年6月2013年9月:博士后,肠道生态系统功能研究实验室(FInE),法国国家农业科学院 (INRA)

研究方向:主要进行人体及动物肠道菌群的研究。以元基因组学、转录组学、代谢组学等手段,分析肠道菌群的结构与功能,节食及功能性食品对肠道菌群的影响,肠道菌群与宿主之间的互作,研究肠道菌群在肥胖等复杂代谢性疾病以及衰老中的作用。

发表论文:

Q. Zhang, Y. Wu, J. Wang, G. Wu, W. Long, Z. Xue, L. Wang, X. Zhang, X. Pang, Y. Zhao, L. Zhao, C. Zhang. Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate- producing bacterium. Scientific reports 6:27572 

C. Zhang, L. Zhao. Strain-level dissection of the contribution of the gut microbiome to human metabolic disease. Genome Medicine (2016) 8:41  

C. Zhang, M. Derrien, F. Levenez, et.al. Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J. 10(9)2235-45 

C. Zhang, H. Li, A, Yin, et.al., Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EbioMedicien. 2 (2015) 968–984 

C. Zhang, S. Li, L. Yang, P. Hang, W. Li, S. Wang, G. Zhao, M. Zhang, X. Pang, Z. Yan, Y. Liu, L. Zhao. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nature communications. 2013, 4: 2163 

C. Zhang, M. Zhang, X. Pang, Y. Zhao, L. Wang, L. Zhao. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. ISME J. 2012 Oct, 6(10):1848-57 

C. Zhang, M. Zhang, S. Wang,R. Han, Y. Cao, W. Hua, Y. Mao, X. Zhang, X. Pang, C. Wei, G. Zhao, Y. Chen, L. Zhao. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J. 2010 Feb, 4(2):232-41 

G. Wu, C. Zhang, J. Wang, F. Zhang, R. Wang,J. Shen, L. Wang, X. Pang, X. Zhang, L. Zhao, M. Zhang. Diminution of the gut resistome after a gut microbiota-targeted dietary intervention in obese children. Scientific reports 6: 24030 

Y. Liu, C. Zhang, L. Zhao, C. Nardini. Adapting functional genomic tools to metagenomic analyses: investigating the role of gut bacteria in relation to obesity.Brief Funct Genomics. 2011 9(5-6): 355-61 

J. Wang, H. Tang, C. Zhang, Y. Zhao, M. Derrien, E. Rocher, J. H. Vlieg, K. Strissel, L. Zhao, M. Obin, J. Shen. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. (2015) 9, 1–15 

J. Wang, H. Tang, C. Zhang, Y. Zhao, M. Derrien, E. Rocher, J. E. van-Hylckama Vlieg, K. Strissel, L. Zhao, M. Obin, J. Shen. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J 2015, 9(1):1-15 

J. H. Vlieg, P. Veiga, C. Zhang, M. Derrien, L. Zhao. Impact of microbial transformation of food on health –from fermented foods to fermentation in the Gastro-Intestinal tract. Current Opinion in Biotechnology, 2011, 22(2):211-219. 

M. Zhang, M. Zhang, C. Zhang, H. Du, G. Wei, X. Pang, H. Zhou, B. Liu, L. Zhao. Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data. FEMS Microbiol Ecol. 2009, 70 (2):21-29 

J. Wang, H. Tang, X. Wang, X. Zhang, C. Zhang, M. Zhang, Y. Zhao, L. Zhao, Shen, J. The structural alteration of gut microbiota in low-birth-weight mice undergoing accelerated postnatal growth. Scientific reports. 6: 27780 

Karl J. P., Fu X., X. Wang, Y. Zhao, J. Shen, C. Zhang, B. E. Wolfe, E. Saltzman, L. Zhao, S. L. Booth. Fecal menaquinone profiles of overweight adults are associated with gut microbiota composition during a gut microbiota-targeted dietary intervention. Am J Clin Nutr 2015, 102(1): 84-93. 

J. Xu, F. Lian, L. Zhao, Y. Zhao, X. Chen, X. Zhang, Y. Guo, C. Zhang, Q. Zhou, Z. Xue, X. Pang, L. Zhao, X. Tong. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J. online publication, 3 October 2014; doi:10.1038. 

Xiao S., Fei N., Pang X., Shen J., Wang L., Zhang B., Zhang M., Zhang X., Zhang C., Li M., Sun, L., Xue Z., Wang J., Feng J., Yan F., Zhao N., Liu J., Long W. and Zhao L. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol 2013, DOI 10.1111/1574-6941.12228. 

X. Zhang, Y. Zhao, M. Zhang, X. Pang, J. Xu, C. Kang, M. Li, C. Zhang, Z. Zhang, Y. Zhang, X. Li, G. Ning, L. Zhao. Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats. Plos One 2012 7(8): e42529. doi:10.1371/journal.pone.0042529 

H. Wei, L. Dong, T. Wang, M. Zhang, W. Hua, C. Zhang, X. Pang, M. Chen, M. Su, Y. Qin, M. Zhou, S. Yang, Z. Chen, M. Rantalainen, JK. Nicholson, W. Jia, D. Wu, L. Zhao. Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure. FEMS Microbial. Ecol. 2010, 73, 577- 586. 

H. Wei, J. Shen, X. Pang, D. Ding, Y. Zhang, B. Zhang, H. Lu, T. Wang, C. Zhang, X. Hua, L. Cui, L. Zhao. Fatal Infection in Human Flora-Associated Piglets Caused by the Opportunistic Pathogen Klebsiella pneumoniae from an Apparently Healthy Human Donor. Laboratory Animal Science 2008, 70(7): 715-717. 

C. Zhang, L. Zhao. Functional Dynamics of Gut Microbiota in Obesity and Metabolic Diseases. (in Chinese). Chinese Bulletin of Life Sciences. 2010 12(7):1247-1253. 

C. Zhang, L. Zhao. Unraveling the roles of Gut microbiota in predisposition to and progression of obesity and related metabolic disorders (in Chinese). Frontier Scicence. 2007, 3: 75-80. 

Y. Zhang, C. Zhang, J. Shen, H. Li, Y. Ni, X. Zhang, L. Zhao, X. Pang. Intestinal microbiota structure of diet-induced obesity rats and its specific molecular marker (in Chinese). Chinese Journal of Microecology. 2009, 21(4): 318-326. 

H. Wei, X. Zhang,C. Zhang, T. Wang, L. Dong, D. Wu, X. Pang, L. Zhao. Intestinal Bifidobacterium quantification in the rats with precancerous lesions of colon cancer induced by DMH (in Chinese). Cancer Research on Prevention and Treatment. 2007, 14(20): 1524-1526. 

W. Hua, Z. Xu, M. Zhang, M. Li, C. Zhang, L. Zhao. The application of CVTree in structural analysis of microbiotal communities by 454 pyrosequecing. Chinese Journal of Microecology, 2010, 22(4): 312-316.

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