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2018-08-24至2018-08-25 上海
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于海军 研究员

中国科学院上海药物研究所

于海军 研究员

中国科学院上海药物研究所

研究方向:

主要从事与 1)智能高分子载药系统设计与合成,2)核酸药物高分子非病毒载体以及 3)高分子载药系统体内过程相关的科研工作。在高分子纳米载药系统的结构调控及体内过程研究方面有多年积累并取得了一定的成绩。在Nano Letters, ACS Nano, Adv Funct Materials, SmallBiomaterials等国际重要学术期刊发表SCI论文80余篇,论文总引用数1500余次。申请中国发明专利8项,授权3项。

承担科研项目情况:

1. 国家自然基金委员会,“纳米载药系统”(优青项目),2017.01-2019.01; 

2. 国家自然基金委员会,“肿瘤微环境自适性纳米载药系统抗乳腺癌转移及其作用机制研究”(面上项目),2017.01-2020.01; 

3. 国家自然基金委员会,“双重酸敏感多层阳离子胶束/RNA复合纳米粒的构建及其用于转移性乳腺癌分子靶向治疗的研究”(面上项目),2014/01-2017/12; 

4. 中国科学院,“药剂学”,2014/01-2017/12 

 

获奖及荣誉:

1. 2015年度中国药学会科学技术奖一等奖(排名第四) 

2. 2014年度中国药学会青年药剂学奖

3. 2013年度赛诺菲-上海生科院优秀青年人才奖 

4. 2013年度上海市药学科技一等奖(排名第四) 

 

代表论著:

1. Dangge Wang, Tingting Wang, Jianping Liu, Haijun Yu,* Shi Jiao, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Zhaocai Zhou, Yaping Li* Cancer Photodynamic Immunotherapy Enhanced by PD-L1 Downregulation With Acid-Activatable Micelleplexes. Nano Letters, 2016, 16, 55035513.

 

2. Bing Feng, Fangyuan Zhou, Tingting Wang, Dangge Wang, Jianping Liu, Qi Yin, Zhiwen Zhang, Zhiai Xu, Haijun Yu*, Yaping Li*. Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy. Adv Funct Mater, 2016, DOI: 10.1002/ adfm.201602963.  

 

3. Tingting Wang, Dangge Wang, Haijun Yu*, Mingwei Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yaping Li* Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/ Chemotherapy of the Drug Resistant Tumor. ACS Nano. 2016, 10, 34963508.

 

4. Dangge Wang, Tingting Wang, Zhiai Xu, Haijun Yu*, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li* Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Loading Docetaxel and siRNA. Small, 2016, 12, 488-498.  

 

5. Fangyuan Zhou, Bing Feng, Haijun Yu*, Dangge Wang, Tingting Wang, Jianping Liu, Qingshuo Meng, Siling Wang,*, Pengcheng Zhang, Zhiwen Zhang, Yaping Li*, Cisplatin Prodrug-Conjugated Gold Nanocluster: A Theranostic Platform for Treatment of Metastatic Breast Cancer. Theranostic, 2016, 6, 679-687.

 

6. Haijun Yu*, Chengyue Guo, Xianzhi Chen, Bing Feng, Jianping Liu, Tingting Wang, Dangge Wang, Zhirui Cui, Qi Yin, Zhiwen Zhang, Yaping Li* Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer. Theranostic, 2016, 6, 14-27.

 

7. Haijun Yu*, Zhirui Cui, Pengcheng Yu, Chengyue Guo, Bing Feng, Tongying Jiang, Siling Wang, Qi Yin, Dafang Zhong, iangliang Yang, Zhiwen Zhang, Yaping Li*. pH and near-infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer. Adv Funct Mater, (Front Cover) 2015, 25, 2489-2500. 


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