UT Southwestern Medical Center
Enterohemorrhagic E. coli (EHEC) sings: pour some sugar on me
Title: Enterohemorrhagic E. coli (EHEC) sings: pour some sugar on me
2014年从葛兰素史克Discovery Fast Track挑战中胜出。
2015年，她获得了2015 Eli Lilly and Co.-Elanco Research Award 研究奖。
Vanessa Sperandio is a professor in the Departments of Microbiology and Biochemistry at UT Southwestern Medical Center. She got her bachelor’s degree in biology and her master’s degree and doctorate in molecular genetics, under the mentorship of Wanderley Dias da Silveira at the State University of Campinas (UNICAMP) in Brazil. Sperandio received a fellowship from the Brazilian government to conduct part of her doctoral research at the University of Maryland School of Medicine, in the laboratory of James B. Kaper, Ph.D., where she would later pursue her postdoctoral training. She joined the faculty in the Microbiology Department at UT Southwestern in 2001.
Sperandio was a Pew Latin American Fellow in the Biomedical Sciences (1997), an Ellison Medical Foundation New Scholar (2004), a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease (2006), and a Kavli Frontiers of Science Fellow (2007). She is the recipient of the 2015 Eli Lilly and Co.-Elanco Research Award, and a winner of the 2014 GlaxoSmithKline Discovery Fast Track Challenge. In 2013, she was elected a fellow of the American Academy of Microbiology. Her research investigates chemical, stress, and nutritional signaling at the interface among the mammalian host, beneﬁcial microbiota, and invading bacterial pathogens. The main tenet of research in her laboratory is the study of how bacterial cells sense several mammalian hormones, leading to rewiring and reprogramming of bacterial transcription toward host and niche adaptation. She has also identiﬁed several bacterial receptors to mammalian hormones and reported that invading pathogens hijack these interkingdom signaling systems to promote virulence expression. She also translated these basic science concepts into strategies to develop novel approaches to antimicrobial therapy.
2. Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V. Fucose sensing regulates bacterial intestinal colonization. Nature. 2012 Dec 6;492(7427):113-7. doi: 10.1038/nature11623. Epub 2012 Nov 18.
4. Sperandio V. Bacterial Reductionism: Host Thiols Enhance Virulence. Cell Host Microbe. 2015 Jul 8;18(1):7-8. doi: 10.1016/j.chom.2015.06.010. (IF=14.946)
5. Moreira CG, Herrera CM, Needham BD, Parker CT, Libby SJ, Fang FC, Trent MS, Sperandio V. Virulence and stress-related periplasmic protein (VisP) in bacterial/host associations.Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1470-5. doi: 10.1073/pnas.1215416110. Epub 2013 Jan 9. (IF=9.661)
6. Kendall MM, Sperandio V. What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations. MBio. 2016 Mar 1;7(2):e01748. doi: 10.1128/mBio.01748-15. Review. (IF=6.956)
You have registered successfully, the registration information and attention has been sent to the contact and the participants of the mailbox, please note that check. If not received, please contact the general meeting