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2018-05-17至2018-05-19 上海
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Mark Gomelsky Professor

University of Wyoming

Developing cell therapies using near-infrared light optogenetics

Mark Gomelsky Professor

演讲题目:Developing cell therapies using near-infrared light optogenetics

University of Wyoming

Dr. Mark Gomelsky is one of the leaders in engineering synthetic, near-infrared light-activated optogenetic circuits to controll human cells in deep tissues. He is a Professor of Molecular Biology at the University of Wyoming and Founder of Eos LABS LLC, a startup company that developes light-activated engineered cells for therapeutic applications. Dr. Gomelsky has been elected as a Fellow of the American Association for the Advancement of Science (AAAS) for discoveries of light-controlled bacterial signal transduction pathways, and for fundamental work on the role of the second messenger cyclic di-GMP in controlling bacterial pathogenesis. He has published >80 articles and is frequently invited as a speaker at international conferences.. Dr. Gomelsky holds Ph.D. in Biological Sciences from Institute of Genetics and Selection of Industrial Microorganisms (Moscow, Russia). Before joining the faculty of the University of Wyoming (1999), he did his postdoctoral studies at Institut Pasteur (Paris, France) and the University of Texas Medical School (Houston, USA). He was Visiting Professor at Max Planck Institute for Medical Research (Heidelberg, Germany; 2007) and Karolinska Institute (Stockholm, Sweden; 2015).


Selected Publications:


First and Corresponding Author:


Gomelsky M. Photoactivated cells link diagnosis and therapy. Sci Transl Med. 2017 Apr 26;9(387). pii: eaan3936. doi: 10.1126/scitranslmed.aan3936.    ( IF 16.796 )


Römling U, Galperin MY, Gomelsky M. Cyclic di-GMP: the first 25 years of a universal bacterial second messenger. Microbiol Mol Biol Rev. 2013 Mar;77(1):1-52. doi: 10.1128/MMBR.00043-12.    ( IF 14.533 )


Gomelsky M, Galperin MY. Bacterial second messengers, cGMP and c-di-GMP, in a quest for regulatory dominance. EMBO J. 2013 Sep 11;32(18):2421-3. doi: 10.1038/emboj.2013.193. Epub 2013 Aug 20.    ( IF 9.792 )


Ryu MH, Kang IH, Nelson MD, Jensen TM, Lyuksyutova AI, Siltberg-Liberles J, Raizen DM, Gomelsky M. Engineering adenylate cyclases regulated by near-infrared window light. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10167-72. doi: 10.1073/pnas.1324301111. Epub 2014 Jun 30.    ( IF 9.661 )


Chen LH, K철seo휓lu VK, G체vener ZT, Myers-Morales T, Reed JM, D'Orazio SE, Miller KW, Gomelsky M. Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes. PLoS Pathog. 2014 Aug 7;10(8):e1004301. doi: 10.1371/journal.ppat.1004301. eCollection 2014 Aug.    ( IF 6.608 )


Others:


2013    1 in MBio    ( IF 6.956 )
2012    1 in Plos Pathog    ( IF 6.608 )

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