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2018-08-24至2018-08-25 上海
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朱鹤 研究员

上海仁济医院干细胞中心

hTERT high Numb-/low Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation with tumor-propagating capacity

朱鹤 研究员

演讲题目:hTERT high Numb-/low Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation with tumor-propagating capacity

上海仁济医院干细胞中心

朱鹤本科毕业于复旦大学,之后赴美国于加州大学圣地亚哥分校医学院(University of California, San Diego)攻读博士学位。博士毕业后留校从事博士后研究工作。2012年回国在上海交通大学附属仁济医院干细胞研究中心历任副研究员、研究员。主要研究领域为成体组织干细胞和肿瘤干细胞的干性调控,以第一作者或通讯作者身份发表SCI论文多篇,包括Gastroenterology,PNAS, Blood,Clinical Cancer Research,Cancer Research,在国际核心期刊杂志发表研究论文27篇,其中第一作者或通讯文章12 篇(影响因子97.6,所有文章总影响因子224.2自作为海外人才引进以来,先后入选上海市浦江人才”、“青年东方学者”特聘教授、“青年科技启明星”和“上海市青年拔尖人才。与此同时,主持国家自然科学基金面上项目多项2014年获选 “九龙医学优秀青年人才奖”

研究方向:

1. 前列腺组织干细胞的分离,及其多能性维持和谱系分化的调控机制

2. 前列腺肿瘤干细胞在抗雄激素耐药和肿瘤转移中的作用和调控机制

3. 造血干细胞和白血病干细胞干性调控的分子机制

 

第一作者或通讯作者论文(*通讯作者)

1. Guo,Y., Zhang, K., Cheng, C., Ji, Z. , Wang, X.,  Wang, M., Chu, M., Tang, D.G., Zhu, H.H.* and Gao, W.Q.* (2017) Numb-/low enriches a castration resistant prostate cancer cell subpopulation associated with enhanced Notch and Hedgehog signaling. Clinical Cancer Research. 23:6744-6756 (影响因子9.6)

2. Zhang, K., Guo, Y., Wang, X., Zhao, H., Ji, Z., Cheng, C., Li, L., Fang, Y., Xu, D., Zhu, H.H.*, and Gao, W.Q.* (2017) WNT/β-catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells. Cancer Research. 77(9):2534-2547. (影响因子9.1)

3. Guo,Y.#, Cui,J.#, Ji, Z., Cheng, C., Zhang, K., Zhang, C.,  Chu,M., Zhao, Q., Yu, Z., Zhang, Y., Fang,Y.X., Gao, W.Q.*, and  Zhu, H.H.*(2017)MiR-302/367/LATS2/YAP Pathway is Essential for Prostate Tumor-Propagating Cells and Promotes the Development of Castration Resistance. Oncogene 36:6336-6347  (影响因子7.5)

4. Zhang, C., Ji, Z., Wang, M., Zhang, W., Yang, R., An, H., Yang, R., Abel, D.V., Dijk, M.V., Yang, X., Ou, G., Zhu, H. H.*, and Gao, W. Q.* (2016) Stox1 as a Novel Transcriptional Suppressor of Math1 during Cerebellar Granule Neurogenesis and Medulloblastoma Formation. Cell Death and Differentiaion. 23, 2042–2053 (影响因子8.3)

5. Zhang, K., Zhao, H., Ji, Z., Zhang, C., Zhou, P., Wang, L., Chen, Q., Wang, J., Zhang, P., Chen, Z., Zhu, H. H.*, and Gao, W. Q.* (2016). Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 10;35(10):1271-82 (影响因子7.5)

6. Zhu, H. H.#, Zhuang, G.#, and Gao, W. Q. (2016). A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis. The Journal of pathology. 238(1):3-6. (影响因子6.9)

7. Zhu, H.H.*, Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z., Zhou, Z., Yao, J., Zeng, L., Ji, K., Gao, W.Q., Zhang, Z.Y., Feng, G.S.* (2015) Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proceedings of the National Academy of Sciences of the United States of America 112: 13342-13347(影响因子9.7)

8. Wang, L., Zhang, K., Zhu, H. H.*, and Gao, W. Q.* (2015). Autonomous assembly of epithelial structures by subrenal implantation of dissociated embryonic inner-ear cells. Neuroreport 26, 473-477. (影响因子1.4)

9. Zhou, Z., Ji, Z., Wang, Y., Li, J., Cao, H., Zhu, H. H.*, and Gao, W. Q.* (2014). TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. Gastroenterology 147, 1043-1054. (影响因子18.4)

10. Zhang, C., Guo, Y., Cui, J., Zhu, H. H.*, and Gao, W. Q.* (2013). Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration. BioMed research international 2013, 576472. (影响因子2.5)

11. Zhu, H. H., Ji, K., Alderson, N., He, Z., Li, S., Liu, W., Zhang, D. E., Li, L., and Feng, G. S. (2011). Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 117, 5350-5361. 影响因子13.2

12. Zhu, H. H., and Feng, G. S. (2011). The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell cycle 10, 2241-2242. 影响因子3.5


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