The origins, convergent and divergent evolution of metazoan microRNAs
演讲题目:The origins, convergent and divergent evolution of metazoan microRNAs
Dr. Jian Lu received his BS and MS degrees from Peking University in 1999 and 2002, respectively. He earned his Ph.D. degree in Ecology and Evolution in 2008 from the University of Chicago under the guidance of Dr. Chung-I Wu. In his Ph.D. study, Jian used a combination of computational and experimental approaches to study the origin and subsequent evolution of Drosophila genomes. After his Ph. D. study, Jian moved to Cornell University and did his postdoc under the supervision of Dr. Andy Clark. At Cornell, Jian studied the regulatory roles of microRNAs in the innate immune response of Drosophila. He extended this work to humans and primate ancestors, showing that genes regulated by miRNAs overall have greater expression variation both among human ethnic groups and among primate species. He also pursued a project on the population dynamics of piRNAs and the transposons that they regulate. Jian set up his own lab at Peking University since from 2013. His lab is currently combining functional and evolutionary genomics to study gene regulation mediated by post-transcriptional regulations such as RNA modifications and small-RNA-mediated regulations in both flies and humans. The ultimate goal of his research is to understand how genotypes affect phenotypes and how natural selection operates during this process.