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2018-03-24至2018-03-25 上海
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姚骏 研究员

清华大学

姚骏 研究员

清华大学

教育经历:

1999, 南京大学生物科学与技术系   学士

2001, 南京大学生物科学与技术系   硕士

2007, 美国宾夕法尼亚州立大学       博士


工作经历:

2007-2011      美国霍华德休斯医学研究所,威斯康星大学      Postdoctoral Research Associate

2011-2013      美国萨克生物学研究所                                       Research Associate

2013-              清华大学生命科学学院                                       研究员


主要研究方向:

1. 利用诱导多能干细胞模型研究复杂神经疾病的致病机理

2. 利用膜片钳和荧光成像技术,研究神经末梢神经递质释放及突触小泡循环利用的机制

3. 研究突触可塑性的机理及其在神经疾病与神经网络形成中的调节


代表性论文:

  1. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, PBDS, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J (2015). Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature. (In Press) 

  2. Yu DX, Di Giorgio DP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmik J, Silberman P, Silberman G, Jappelli R, Gage FH (2014). Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Feb 27;2(3):295-310. doi: 10.1016/j.stemcr.2014.01.009. eCollection 2014 Mar 11.

  3. Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER (2012). Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nature Neuroscience. 15(2): 243-249.

  4. Yao J, Gaffaney JD, Kwon SE, Chapman ER (2011). Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell. 147(3):666-77.

  5. Yao J, Mu Y, Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein & Cell. 3(4): 251-261. (Review)

  6. Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER (2012). All three components of the neuronal SNARE complex contribute to secretory vesicle docking in PC12 cells. Journal of Cell Biology. 198(3):323-30. 

  7. Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER (2010). SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathogens. 6(11): e1001207.

  8. Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B (2008). Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Molecular and Cellular Neuroscience. 38(2):277-289.

  9. Deng, L.*, Yao, J.*, Fang, C., Dong, N., Luscher, B., Chen G (2007). Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. Journal of Neuroscience. 27(40):10860-9. (*Equal contribution)

  10. Yao, J., Qi, J. S., and Chen, G (2006). Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons. Journal of Neuroscience. 26(31):8137-47.

  11. Qi, J., Yao, J., Fang, C., Luscher, B., and Chen G (2006). Downregulation of Tonic GABA Currents Following Epileptogenic Stimulation of Rat Hippocampal Cultures. Journal of Physiology. 577(2): 579-590.

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