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2018-03-24至2018-03-25 上海
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刘光慧 教授

中国科学院生物物理研究所

Using stem cell and gene editing techniques to study and treat aging-associated disorders

刘光慧 教授

演讲题目:Using stem cell and gene editing techniques to study and treat aging-associated disorders

中国科学院生物物理研究所

中科院生物物理研究所研究员,中国科学院大学岗位教授。干细胞国家重大科学研究计划(973)项目首席科学家,国家杰出青年科学基金获得者。现任中国老年医学学会基础与转化医学分会副会长,中国细胞生物学会再生细胞生物学分会副会长,中国老年医学研究机构联盟副主任委员,中国老年学和老年医学学会抗衰老分会副主任委员,中国细胞生物学学会干细胞生物学分会委员,中国生物物理学会理事,Protein & Cell 杂志副主编。近年来在人类衰老和再生医学领域取得了系列原创性研究成果。以高级作者身份在 Nature(2)、Science、Cell、Cell Stem Cell(2)、Nature Communications(2)和 Cell Res(2)等刊物发表系列研究论文。授权或申请发明专利(第一发明人)14 项。获首届老年医学杰出贡献奖。


Selected Publications:


Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T#, Qu J#, Liu GH#. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Res. 2017. 27(4):483-504. (#Corresponding author)    ( IF 15.606 )


Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J#, Tang F#, Liu GH#. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017. doi:10.1038/cr.2017 (#Corresponding author)    ( IF 15.606 )


Ren R, Ocampo A, Liu GH#, Belmonte JC#. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017. j.cmet.2017.07.019 (#Corresponding author)    ( IF 18.164 )

  

Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y#, Qu J#, Liu GH#. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosispatient iPSCs. Protein Cell. 2017. DOI 10.1007/s13238-017-0397-3.( #Corresponding author)    ( IF 5.374 )


Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH#, Misteli T#, Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016. 165(6):1361-74 (#Corresponding author)


Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J#, Tang F#, Liu GH#. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016. 26(2):190-205. (#Corresponding author)     ( IF 15.606 )


Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature. 2016. 540(7631):144-149.


Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507    ( IF 23.394 )


Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC#, Qu J#, Liu GH#. Modeling Xeroderma Pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell. 2016. 7(3):210-21. (#Corresponding author)    ( IF 5.374 )


Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J#, Zhang W#, Liu GH#. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016. 7(7):478-88. (#Corresponding author)    ( IF 5.374 )


Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F#, Liu GH#, Belmonte JC#. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015. 348(6239):1160-3. (#Corresponding author)


Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell. 2015. 161:459-469


Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J#, Tang F#, Liu GH#. PTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015. 6:10068. (#Corresponding author)     ( IF 12.124 )


Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla R, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH#, Li Y#, Belmonte JC#. Targeted gene correction in human disease-specific induced pluripotent stem cells minimally impacts whole-genome mutational load. Cell Stem Cell. 2014. 15, 31–36. (#Corresponding author)    ( IF 23.394 )


Liu GH#, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla R, Goebl A, Aizawa E, Kim N, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo J, Surralles J, Esteban C, Izpisua Belmonte JC#. Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs. Nat Commun. 2014. 7;5:4330. (#Corresponding author)    ( IF 12.124 )


Yang J, Cai N, Yi F, Liu GH#, Qu J#, Belmonte JC#. Gating pluripotency via nuclear pores. Trends Mol Med. 2014. 20(1):1-7. (#Corresponding author)    ( IF 10.732 )


Wu K, Ren R, Su W, Wen Bo, Zhang Yuying, Yi Fei, Qiao X, Yuan T, Wang J, Liu L, Belmonte JC#, Liu GH#, Chen C#. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014. 289(29):20193-9. (#Corresponding author)    ( IF 4.125 )


Xu XL#, Yang JP, Fu LN, Ren RT, Yi F, Suzuki K, Liu K, Ding ZC, Qu J, Zhang WQ, Li Y, Yuan TT, Yuan GH, Sui LN, Guan D, Duan SL, Pan HZ, Wang P, Zhu XP, Montserrat N, Li M, Bai RJ, Liu L, Izpisua Belmonte JC, Liu GH#. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein Cell. 2014. 5(1):4-7. (#Corresponding author)    ( IF 5.374 )


Xu X, Duan S, Yi F, Ocampo A, Liu GH#, Belmonte JC#. Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013. 18:325-32. (#Corresponding author)    ( IF 18.164 )


Pan H, Cai N, Li M, Liu GH#, Belmonte JC#. Autophagic control of cell stemness. EMBO Mol. Med. 2013. 5(3):327-31. (#Corresponding author)    ( IF 9.249 )


Zhang WQ, Qu J, Suzuki K, Liu GH#, Belmonte JC#. Concealing cellular defects in pluripotent stem cells. Trends Cell Biol. 2013. 23(12):587-92. (#Corresponding author)    ( IF 15.333 )


Guan D, Zhang W, Zhang W#, Liu GH#, Belmonte JC#. Switching cell fate, ncRNAs coming to play. Cell Death Dis. 2013.17;4:e464. (#Corresponding author)    ( IF 5.965 )


Liu GH#, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Ren B, Wagner U, Kim A, Li Y, Goebl A, Kim J, Soligalla R, Dubova I, Thompson J, Yates J III, Esteban C, Sancho-Martinez I, Belmonte JC#. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012. 491:603-7. (#Corresponding author)


Li M*, Liu GH*, Belmonte JC. Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol. 2012; 13(8):524-35. (*equal contribution)    ( IF 46.602 )


Liu GH#, Ding Z, Izpisua Belmonte JC#. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol. 2012. 24(6):765-74 (#Corresponding author)    ( IF 9.937 )


Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012. 109(31):12556-61    ( IF 9.661 )


Liu GH*, Suzuki K*, Qu J*, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring J, Laurent L, and Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011. 8(6):688-94. (*equal contribution)    ( IF 23.394 )


Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, III JY, Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011. 14;472: 221-5


Book Chapter:


Liu GH#, Yang J, Ding Z, Ocampo A, Qu J, Suzuki K, Izpisua Belmonte JC#. Chapter: iPSC disease modeling of laminopathies. Human iPS Cells in Disease Modeling (Springer). 2016. pp 53-67 (#Corresponding author)

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