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2017-09-22至2017-09-23 中国上海
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李兰娟 工程院院士

浙江大学附属第一医院

李兰娟 工程院院士

浙江大学附属第一医院

浙江大学教授、主任医师、博士生导师、传染病学专家。卫生部传染病重点实验室主任、中华医学会副会长。中华医学会感染病学分会副主任委员、全国人工肝培训基地主任。2005 年当选为中国工程院院士。创建独特有效的人工肝支持系统治疗重型肝炎(ALSS)获重大突破。建立我国第一个永生化人源性肝细胞系;创建四步灌流分离肝细胞新方法;构建新型混合型人工肝。主编专著11 部,其中《传染病学》系教育部全国高等学校医学规划教材,《人工肝脏》、《感染微生态》均为中国该领域的首部专著。首次提出感染微生态学理论,从微生态角度来审视感染的发生、发展和结局,为感染防治提供了崭新的思路,还从基因的角度首次揭示肠道菌群与肝硬化的秘密。提出B/E值为肠道定植抗力的新指标,为肠道微生态基础和应用研究提供了客观依据;首次揭示重型肝炎病人肠道微生态变化规律,阐明了肠道微生态变化与重型肝炎发生、发展的关系,丰富了重型肝炎发病机制的理论;发表论文400余篇,其中在Nature、Lancet、NEJM等SCI收录杂志发表200余篇,主编著作29部。获得国家科技进步一等奖2项,二等奖2项,省科技进步一等奖6项。

主要发表论著:


Shi H, Lv L, Cao H, Lu H, Zhou N, Yang J, Jiang H, Dong H, Hu X, Yu W, Jiang X, Zheng B, Li L. Bacterial translocation aggravates CCl4-induced liver cirrhosis by regulating CD4+ T cells in rats. Sci Rep. 2017 Jan 30;7:40516. doi: 10.1038/srep40516.


Chen D, Su X, Wang N, Li Y, Yin H, Li L, Li L. Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model. Sci Rep. 2017 Jan 16;7:40543. doi: 10.1038/srep40543.


Liu F, Ling Z, Xiao Y, Lv L, Yang Q, Wang B, Lu H, Zheng L, Jiang P, Wang W, Li L.Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus. Oncotarget. 2017 Jan 17;8(3):3798-3810. doi: 10.18632/oncotarget.14028.


Ling Z, Liu X, Cheng Y, Shao L, Jiang H, Li L. Blood microbiota as a potential noninvasive diagnostic biomarker for liver fibrosis in severely obese patients: Choose carefully. Hepatology. 2016 Dec 20. doi: 10.1002/hep.28987


Zheng B, Xu H, Li A, Ji J, Wang Y, Xiao Y, Li L. Community-associated meticillin-resistant Staphylococcus aureus pneumonia in China. Lancet Infect Dis. 2017 Jan;17(1):26. doi: 10.1016/S1473-3099(16)30554-0


Zhang J, Zhou K, Zheng B, Zhao L, Shen P, Ji J, Wei Z, Li L, Zhou J, Xiao Y.High Prevalence of ESBL-Producing Klebsiella pneumoniae Causing Community-Onset Infections in China. Front Microbiol. 2016 Nov 15;7:1830.


Sun Z, Liu X, Jiang J, Huang H, Wang J, Wu D, Li L.Toward Biomarker Development in Large Clinical Cohorts: An Integrated High-Throughput 96-Well-Plate-Based Sample Preparation Workflow for Versatile Downstream Proteomic Analyses. Anal Chem. 2016 Sep 6;88(17):8518-25.


Ling Z, Liu X, Cheng Y, Li L.Predictive roles of gut dysbiosis on the severity of nonalcoholic fatty liver disease. Hepatology. 2016 Sep;64(3):993-4.


Cao B, Gao H, Zhou B, Deng X, Hu C, Deng C, Lu H, Li Y, Gan J, Liu J, Li H, Zhang Y, Yang Y, Fang Q, Shen Y, Gu Q, Zhou X, Zhao W, Pu Z, Chen L, Sun B, Liu X, Hamilton CD, Li L.Adjuvant Corticosteroid Treatment in Adults With Influenza A (H7N9) Viral Pneumonia. Crit Care Med. 2016 Jun;44(6):e318-28.


Shi D, Zhang J, Zhou Q, Xin J, Jiang J, Jiang L, Wu T, Li J, Ding W, Li J, Sun S, Li J, Zhou N, Zhang L, Jin L, Hao S, Chen P, Cao H, Li M, Li L, Chen X, Li J. Quantitative evaluation of human bone mesenchymal stem cells rescuing fulminant hepatic failure in pigs. Gut. 2016 Feb 16. pii: gutjnl-2015-311146


Su X, Wang N, Chen D, Li Y, Lu Y, Huan T, Xu W, Li L, Li L.Dansylation isotope labeling liquid chromatography mass spectrometry for parallel profiling of human urinary and fecal submetabolomes. Anal Chim Acta. 2016 Jan 15;903:100-9


Zheng B, Zhang J, Ji J, Fang Y, Shen P, Ying C, Lv J, Xiao Y, Li L.Emergence of Raoultella ornithinolytica coproducing IMP-4 and KPC-2 carbapenemases in China. Antimicrob Agents Chemother. 2015 Nov;59(11):7086-9.


Xin J, Ding W, Hao S, Chen X, Zhang J, Jiang L, Zhou Q, Shi D, Zhang L, Xu X, Cao H, Li L, Li J.Serum macrophage inflammatory protein 3α levels predict the severity of HBV-related acute-on-chronic liver failure. Gut. 2016 Feb;65(2):355-7.


Zhou N, Li J, Zhang Y, Lu J, Chen E, Du W, Wang J, Pan X, Zhu D, Yang Y, Chen Y, Cao H, Li L.Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating pigs with acute liver failure: A randomised study. J Hepatol. 2015 Aug;63(2):378-87.


Xin J, Ding W, Hao S, Jiang L, Zhou Q, Wu T, Shi D, Cao H, Li L, Li J.Human bone marrow mesenchymal stem cell-derived hepatocytes express tissue inhibitor of metalloproteinases 4 and follistatin. Liver Int. 2015 Oct;35(10):2301-10


Yu C, Gong X, Yang Q, Lian J, Xu K, Ruan B, Li L.The serum IL-23 level predicts the response to pegylated interferon therapy in patients with chronic hepatitis B. Liver Int. 2015 May;35(5):1549-56. doi: 10.1111/liv.12701.


Qin N, Yang F, Li A, Prifti E, Chen Y, Shao L, Guo J, Le Chatelier E, Yao J, Wu L, Zhou J, Ni S, Liu L, Pons N, Batto JM, Kennedy SP, Leonard P, Yuan C, Ding W, Chen Y, Hu X, Zheng B, Qian G, Xu W, Ehrlich SD, Zheng S, Li L.Alterations of the human gut microbiome in liver cirrhosis. Nature. 2014 Sep 4;513(7516):59-64.


Huang F, Guo J, Zou Z, Liu J, Cao B, Zhang S, Li H, Wang W, Sheng M, Liu S, Pan J, Bao C, Zeng M, Xiao H, Qian G, Hu X, Chen Y, Chen Y, Zhao Y, Liu Q, Zhou H, Zhu J, Gao H, Yang S, Liu X, Zheng S, Yang J, Diao H, Cao H, Wu Y, Zhao M, Tan S, Guo D, Zhao X, Ye Y, Wu W, Xu Y, Penninger JM, Li D, Gao GF, Jiang C, Li L.Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. 2014 May 6;5:3595. doi: 10.1038/ncomms4595.


Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY.Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. 2013 Jun 1;381(9881):1916-25


Xiao Y, Li L.Legislation of clinical antibiotic use in China.Lancet Infect Dis. 2013 Mar;13(3):189-91.


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