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2017-11-24至2017-11-25 中国上海
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赵立平 教授

上海交通大学

赵立平 教授

上海交通大学

赵立平,上海交通大学生命科学技术学院微生物学特聘教授,微生物分子生态学与生态基因组学实验室主任,上海系统生物医学研究中心营养系统生物学实验室主任,上海交大-完美中国微生态健康联合研究中心主任。1989年南京农业大学博士毕业。1993-1995康奈尔大学访问学者。2004-2012担任上海交通大学生命科学技术学院副院长。2005-2009,上海系统生物医学研究中心常务副主任。2009年度上海市优秀学科带头人。2006-2012担任国际微生物生态学会(ISME)常务理事。 Journal of Molecular Medicine,FEMS Microbiology Ecology,Microbial Biotechnology等国际刊物编委;ISME Journal(国际微生物生态学会会刊,影响因子9.276)的资深编辑,Scientific Report编委。2014年被选为美国微生物科学院院士。

他领导的团队是国际知名的微生物分子生态学研究小组,在复杂微生物群落结构分析技术和统计计算方法、结构与功能相关性等方面做了很多创新性工作,特别在肠道菌群与肥胖等代谢性疾病的关系研究中,提出“代谢性疾病的肠源性学说”,发现并验证了首例能够引起肥胖症的人体肠道细菌。在美国科学院院报(PNAS), 国际微生物生态学会会刊(ISME Journal)、Nature Communications、Nature Reviews Microbiology等刊物发表论文四十余篇。应邀在国际微生物生态学大会、国际人类微生物组大会、国际糖尿病技术大会、美国微生物学会年会等一系列国际会议做大会报告、特邀报告。目前的研究重点是,营养如何通过改变菌群从而影响代谢性疾病的发生和发展,以及如何挖掘、利用中国传统养生食材和中医药中的有效成分,通过调理菌群结构进行代谢性疾病的预防和治疗。2012年6月,美国《科学》周刊曾对他的研究工作做过专题报道(Science 336: 1248)。

代表性论文:

1.  Fei, N. and Zhao LP*. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. ISME J. 2012, doi: 10.1038/ismej.2012.153.

2.  Zhang, X., et al., Zhao LP*. Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats. PLOS ONE, 2012. 7(8): p. e42529.

3.  Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao LP*. Symbiotic gut microbes modulate human metabolic phenotypes. PNAS. 2008, 105(6):2117-22. 

其他论文:

1.    Chenhong Zhang, Aihua Yin, Hongde Li, Ruirui Wang, Guojun Wu, Jian Shen, Menghui Zhang, Linghua Wang, Yaping Hou, Haimei Ouyang, Yan Zhang, Yinan Zheng, Jicheng Wang, Xiaofei Lv, Yulan Wang, Feng Zhang, Benhua Zeng, Wenxia Li, Feiyan Yan, Yufeng Zhao, Xiaoyan Pang, Xiaojun Zhang, Huaqing Fu, Feng Chen, Naisi Zhao, Bruce R. Hamaker, Laura C. Bridgewater, David Weinkove, Karine Clement, Joel Dore, Elaine Holmes, Huasheng Xiao, Guoping Zhao, Shengli Yang, Peer Bork, Jeremy K. Nicholson, Hong Wei, Huiru Tang, Xiaozhuang Zhang, Liping Zhao, Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children, EBioMedicine, 2015, 8(2):968-984, doi:10.1016/j.ebiom.2015.07.007

Xu Zhang, Yufeng Zhao, Jia Xu, Zhengsheng Xue, Menghui Zhang, Xiaoyan Pang, Xiaojun Zhang, and Liping Zhao.  Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Scientific Report, 2015, 5, 14405; doi: 10.1038/srep14405 (2015).

Zhengsheng Xue, Wenping Zhang, Linghua Wang, Rong Hou, Menghui Zhang, Lisong Fei, Xiaojun Zhang, He Huang, Laura C. Bridgewater, Yi Jiang, Chenglin Jiang, Liping Zhao, Xiaoyan Pang, Zhihe Zhang. The bamboo-eating giant panda harbors a carnivore-like gut microbiota, with excessive seasonal variations. mBio. 2015, 6(2):e00022-15. DOI:10.1128/mBio.00022-15 ?

Jiachao Zhang, Zhuang Guo, Zhengsheng Xue, Zhihong Sun, Menghui Zhang, Lifeng Wang, Guoyang Wang, Fang Wang, Jie Xu, Hongfang Cao, Haiyan Xu, Qiang Lv, Zhi Zhong, Yongfu Chen, Sudu Qimuge, Bilige Menghe, Yi Zheng, Liping Zhao, Wei Chen and Heping Zhang.  A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities. The ISME Journal  2015, online publication, 3 February 2015; doi:10.1038/ismej.2015.11

Hui Chen, Ying Liu, Menghui Zhang, Guoyang Wang, Zhengnan Qi, Laura Bridgewater, Liping Zhao, Zisheng Tang and Xiaoyan Pang. A Filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats. Scientific Reports 2015; online publication, 12 March 2015; doi:10.1038/srep09053.

Ren H, Gao G, Song Z, Wang W, Zhao L, Zhang X.  Bacteria in the injection water differently impacts the bacterial communities of production wells in high-temperature petroleum reservoirs.  Frontiers in Microbiology, 2015; 6:505. DOI:10.3389/fmicb.2015.00505  3.94 Impact Factor

Jia Xu, Fengmei Lian, Linhua Zhao, Yufeng Zhao, Liping Zhao, and Xiaolin Tong. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J 2015, 9(3):552-62. doi:10.1038/ismej.2014.177.

Jingjing Wang, Huang Tang, Chenhong Zhang, Yufeng Zhao, Muriel Derrien, Emilie Rocher, Johan ET van-Hylckama Vlieg, Katherine Strissel, Liping Zhao, Martin Obin, and Jian Shen. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J 2015, 9(1):1-15. doi: 10.1038/ismej.2014.99.

Li W, Deng GC, Li M, Zeng J, Zhao LP, Liu XM, Wang YJ. A recombinant adenovirus expressing CFP10, ESAT6, Ag85Aand Ag85B of Mycobacterium tuberculosis elicits strong antigen-specific immune responses in mice. Mol. Immunol., 2014, 62(1) 86-95.

Feng, J., H. Tang, M. Li, X. Pang, L. Wang, M. Zhang, Y. Zhao, X. Zhang, J. Shen*. The abundance of fecal Faecalibacterium prausnitzii in relation to obesity and gender in Chinese adults. Archives of Microbiology, 2014,196(1):73-77.

Shunzi Xiong, Xia Li, Jianfa Chen, Liping Zhao, Hui Zhang, Xiaojun Zhang. Crude oil degradation by bacterial consortia under four different redox and temperature conditions. Applied Microbial and Biotechnology, 2014,99(3):1451-61 online published, doi:10.1007/s00253-014-6042-7. ( IF:3.811)

Fei Huang, Ling Ge, Bo Zhang, Yun Wang, Hao Tian, Liping Zhao, Yiliang He, Xiaojun Zhang. A fullerene colloidal suspension stimulates the growth and denitrification ability of wastewater treatment sludge derived bacteria. Chemosphere, 2014,108:411?417.  ( IF:3.137)

Shuiming Xiao, Liping Zhao*, Gut microbiota-based translational biomarkers to prevent metabolic syndrome via nutritional modulation, FEMS Microbiology Ecology, 87(2), 303-314, 2014.

Shuiming Xiao, Na Fei, Xiaoyan Pang, Jian Shen, Linghua Wang, Baorang Zhang, Menghui Zhang, Xiaojun Zhang, Chenhong Zhang, Min Li, Lifeng Sun, Zhengsheng Xue, Jingjing Wang, Jie Feng, Feiyan Yan, Naisi Zhao, Jiaqi Liu, Wenmin Long, Liping Zhao. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome, FEMS Microbiology Ecology,2013, 87(2):357-67 .doi: 10.1111/1574-6941.12228.

Lauren A. Zenewicz, Xiaochen Yin, Guoyang Wang, Eran Elinav, Liming Hao, Liping Zhao, and Richard A. Flavell.  IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic. J Immunol  2013 190:5306-5312;

Zhao L.  The gut microbiota and obesity: from correlation to causality. Nature Reviews Microbiology.2013, 11:639?647.doi:10.1038/nrmicro3089

Zhang C., Li S., Yang L., Hang P., Li W., Wang S., Zhao G., Zhang M., Pang X., Yan Z., Liu Y., Zhao L.. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nature Communications.2013,4,2163, doi:10.1038/ncomms3163.

Yin XPeng JZhao LYu YZhang XLiu PFeng QHu YPang X.Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula. Syst Appl Microbiol. 2013,36(3):188-96.

Zhao L, Nicholson JK, Lu A, Wang Z, Tang H, Holmes E, Shen J, Zhang X, Li JV, Lindon JC.. Targeting the Human Genome?Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine. J Proteome Res. 2012 Jun 5, DOI: http://dx.doi.org/10.1021/pr3001628.
Zhang Chenhong, Zhang Menghui, Pang Xiaoyan, Zhao Yufeng, Wang Linghua and Zhao Liping. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. The ISME Journal, doi:10.1038/ismej.2012.27.
Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S and Zhao L. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. The ISME Journal, doi:10.1038/ismej.2011.109.
Zhang Xu, Zhao Yufeng, Hu Yiyang, Liu Ping, Zhao Liping. Gut Microbiota-targeted, Whole-Body Systems Biology for Understanding Traditional Chinese Medicine. World Science and Technology, 2011, 13(2):202-212.
Zhu, J., Yin, X., Yu, H., Zhao, L., Sabour, P., Gong, J. Involvement of quorum sensing and heat-stable enterotoxin a in cell damage caused by a porcine enterotoxigenic Escherichia coli strain Infection and Immunity 2011, 79 (4):1688-1695.
van Hylckama Vlieg, J.E.T., Veiga, P., Zhang, C., Derrien, M., Zhao, L.  Impact of microbial transformation of food on health-from fermented foods to fermentation in the gastro-intestinal tract. Current Opinion in Biotechnology 2011,22 (2):211-219.
Ren H, Zhang XSong Z, Rupert W, Gao G, Guo S, Zhao L. Comparison of Microbial Community Compositions of Injection and Production Well Samples in a Long-term Water-Flooded Petroleum Reservoir. Plos One, 2011,6(8): e23258. doi:10.1371/journal.pone.0023258
Zhao L, Shen J.. Functional Metagenomics and Systems Biology: understanding the human organismal complexity in disease and health. 2011. In Metagenomics: Current Innovations and Future Trends, D. Marco, ed. (Horizon Scientific Press) (Book chapter)

 Zhang XYue S, Zhong H, Hua W, Chen R, Cao Y,  and Zhao L. A diverse bacterial community in an anoxic quinoline-degrading bioreactor determined by using pyrosequencing and clone library analysis. Applied Microbial and Biotechnology, 2011, 91:425?434.
Wang Tingting, Zhang Xiaojun, Zhang Menghui, Wang Linghua, Zhao Liping. Development of a fluorophore-ribosomal DNA restriction typing method for monitoring structural shifts of microbial communities. Archives in Microbiology, 2011, 193:341?350.
Liu Y, Zhang C, Zhao L and Nardini C.  Adapting functional genomic tools to metagenomic analyses: investigating the role of gut bacteria in relation to obesity.Briefings in Functional Genomics,  2010, doi: 10.1093/bfgp/elq011
Shen J., B. Zhang, H. Wei, C. Che, D. Ding, X. Hua, P. Bucheli, L. Wang, Y. Li, X. Pang, L. Zhao. Assessment of the modulating effects of fructo-oligosaccharides on fecal microbiota using human flora associated piglets. Archives of Microbiology. 2010, 192:959-968

 Hong X, Zhang X, Liu B, Mao Y, Liu Y, and Zhao L. Structural differentiation of microbial communities in two efficient indole degrading bioreactors using different treatment processes. Research in Microbiology, 2010,161(8): 687-693.

 Mao Y, Zhang X, Xia X, Zhong H, Zhao L. Versatile aromatic compound-degrading capacity and microdiversity of Thauera strains isolated from a coking wastewater treatment bioreactor. J Ind Microbiol Biotechnol. 2010,37:927-934.
Wei  H, Dong L, Wang T, Zhang M, Hua W,  Zhang C, Pang X, Chen M, Su M, Qiu Y, Zhou M, Yang S, Chen Z, Rantalainen M, Nicholson J.K., Jia W, Wu D&  Zhao L. Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure. FEMS Microbiol Ecol, 2010, 73:577-586.
Zhao Liping and Shen Jian. Whole-body systems approaches for gut microbiota-targeted, preventive healthcare. Journal of Biotechnology, 2010,
Mao Y, Zhang X, Yan X, Liu B, Zhao L. Development of group-specific PCR-DGGE fingerprinting for monitoring structural changes of Thaueraspp. in an industrial wastewater treatment plant responding to operational perturbations. J Microbiol Methods. 2008, 75: 231?236. (SCIIF:2.153)
Wei H., Shen J., Pang X., Ding D., Zhang Y., Zhang B., Lu H., Wang T., Zhang C., Hua X., Cui L., Zhao L., Fatal Infection in Human Flora-Associated Piglets Caused by the Opportunistic Pathogen Klebsiella pneumoniae from an Apparently Healthy Human Donor, J. Vet. Med. Sci.2008, 70(7): 715?717. (SCI )
Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M,Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A. 2008, 105(6):2117-22. (SCI IF:9.598)
Jia WLi  H, Zhao L & J. K. Nicholson. Gut microbiota: a potential new territory for drug targeting.  Nature Reviews Drug Discovery,2008, 7:123-129. (SCI IF:23.308)
Yang C,Cao G, Li Y, Zhang X, Ren H, Wang X, Feng J, Zhao L, Xu P.  A Constructed Alkaline Consortium and Its Dynamics in Treating Alkaline Black Liquor with Very High Pollution Load. Plos One, 2008, 3(11):e3777. Epub 2008 Nov 20.
Piao Z, Yang L, Zhao L, Yin S. Actinobacterial community structure in soils receiving long-term organic and inorganic amendments. Appl Environ Microbiol.  2008, 74(2): 526-30. (SCI IF:4.004)
Mao, Y., L. R. Bakken, L. Zhao, and A. Frostegard. Functional robustness and gene pools of a wastewater nitrification reactor: comparison of dispersed and intact biofilms when stressed by low oxygen and low pH. FEMS Microbiol Ecol 2008, 66:167-180.. (SCI IF:3.039)
Wang H, Zhang X, Zhao L, Xu Y. Analysis and comparison of the bacterial community in fermented grains during the fermentation for two different styles of Chinese liquor. J Ind Microbiol Biotechnol., 2008, 35:603?609. (SCI IF: 1.681)
Zhu CG (Zhu, Chenguang), Zhang LY (Zhang, Liye), Zhao LP (Zhao, Liping). Molecular cloning, genetic organization of gene cluster encoding phenol hydroxylase and catechol 2,3-dioxygenase in Alcaligenes faecalis IS-46. World Journal Microbiology & Biotechnology,2008,24: 1687-1695. (SCI IF: 0.745).
Pang X, X Hua, Q Yang,D Ding, C Che, L Cui, W jia, P Bucheli and L Zhao. Inter-species transplantation of gut microbiota from human to pigs. The ISME Journal, 2007, 1(2):156-162. Zhang M, B Liu, Y Zhang, H Wei, Y Lei, and L Zhao, Structural shifts of mucosa-associated Lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis, Journal of Clinical Microbiology. , 2007, 45(2):496-500 (SCI IF:3.708)
Yan X, Z Xu, X Feng, Y Liu, B Liu, X Zhang, C Zhu, L Zhao. Cloning of Environmental Genomic Fragments as Physical Markers for monitoring Microbial populations in Coking Wsatewater Treatment System. Microbial Ecology., 2007, 53:163-172 (SCI IF:2.558)
Wei G, Lu H, Zhou Z, Xie H, Wang A, Nelson K, Zhao L. The microbial community in the feces of the giant panda (Ailuropoda melanoleuca) as determined by PCR-TGGE profiling and clone library analysis. Microb Ecol, 2007, 54(1):194-202 (SCI IF:2.558)
Li, K.; Guan, W.; Wei, G.; Liu, B.; Xu, J.; Zhao, L.; Zhang, Y. Phylogenetic analysis of intestinal bacteria in the Chinese mitten crab (Eriocheir sinensis). Journal of Applied Microbiology, 2007, 103: 675-682. (SCI IF:2.206)
Wang X, Su M, Qiu Y, Ni Y, Zhao T, Zhou M, Zhao A, Yang S, Zhao L, Jia W.  Metabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention. J Proteome Res. 2007, 6(9):3449-55. ( SCI )
Li H, Ni Y, Su M, Qiu Y, Zhou M, Qiu M, Zhao A, Zhao L, Jia W. Pharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats. J Proteome Res. 2007, 6(4):1364-70. ( SCI )
Binbin Liu, Feng Zhang, Xiaoxi Feng, Yongdi Liu, Xing Yan, Xiaojun Zhang, Linghua Wang, Liping Zhao.Thauera and Azoarcus as Functionally Important Genera in a Denitrifying Quinoline Removal Bioreactor as Revealed by Microbial Community Structure Comparison. FEMS Microbiology Ecology,2006,55(2):274-86.(SCI IF3.039)
Jian Shen, Baorang Zhang, Guifang Wei, Xiaoyan Pang, Hua Wei, Min Li, Yan Zhang, Wei Jia, and Liping Zhao. ?Molecular Profiling of the Clostridium leptum Subgroup in Human Fecal Microflora by PCR-Denaturing Gradient Gel Electrophoresis and Clone Library Analysis. Applied and Environmental Microbiology, 2006,72(8):5232-5238.
Minjun Chen, Mingming Su, Liping Zhao, Jian Jiang, Ping Liu, Jiye Cheng, Yijiang Lai, Yumin Liu, Wei Jia*, Metabonomic Study of Aristolochic Acid-Induced Nephrotoxicity in Rats, Journal of proteom research. 2006, 5:995-1002. ( SCI )
Xiang, H., G. F. Wei, S. Jia, J. Huang, X. X. Miao, Z. Zhou, L. Zhao, and Y. P. Huang. Microbial communities in the larval midgut of laboratory and field populations of cotton bollworm (Helicoverpa armigera). Can J Microbiol, 2006, 52:1085-92. ( SCI )
Zhang, X., X. Yan, P. Gao, L. Wang, Z. Zhou, and L. Zhao. Optimized sequence retrieval from single bands of temperature gradient gel electrophoresis profiles of the amplified 16S rDNA fragments from an activated sludge system. J Microbiol Methods, 2005, 60:1-11. ( SCI )
Zhao Y., W. Li, Z. Zhou, L. Wang, Y. Pan, L. Zhao..Dynamics of Microbial Community Structure and Cellulolytic Activity in Agricultural Soil Amended with two Biofertilizers. European Journal of Soil Biology. 2005, 41:21-29. ( SCI )
Pang, X., D. Ding, G. Wei, M. Zhang, L. Wang, and L. Zhao. Molecular profiling of Bacteroides spp. in human feces by PCR-temperature gradient gel electrophoresis. J Microbiol Methods. 2005, 61:413-417. ( SCI )
Cao, Y, L. Wang, K. Xu, C. Kou,Y. Zhang, G. Wei, J. He, Y. Wang, L. Zhao.Information theory-based algorithm for in silico prediction of PCR products with whole genomic sequences as templates. BMC Bioinformatics, 2005, 6(1):190. ( SCI )
Minjun Chen, Liping Zhao, and Wei Jia*, Metabonomic Study on the Biochemical Profiles of A Hydrocortisone-Induced Animal Model,Journal of proteome research, 2005, 4: 2391- 2396. ( SCI )
Wei, G., L. Pan, H. Du, J. Chen, and L. Zhao. ERIC-PCR fingerprinting-based community DNA hybridization to pinpoint genome-specific fragments as molecular markers to identify and track populations common to healthy human guts. J Microbiol Methods 2004, 59:91-108. ( SCI )
Zhang, X., P. Gao, Q. Chao, L. Wang, E. Senior, and L. Zhao. Microdiversity of phenol- hydroxylase genes among phenol-degrading isolates of Alcaligenes sp. from an activated sludge system. FEMS Microbiol Lett 2004, 237:369-75. ( SCI )

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