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2017-07-21至2017-07-22
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赵健元 副研究员

复旦大学生命科学学院

赵健元 副研究员

复旦大学生命科学学院

个人简介:赵健元,复旦大学生命科学学院副研究员,博士生导师。2011年博士毕业于复旦大学。之后赴美国约翰霍普金斯大学医学院从事博士后研究工作。2013年全职回国,入职复旦大学生科院。主要从遗传变异和代谢失调的角度出发,在分子细胞水平研究出生缺陷的发生机理。近5年来以第一或通讯作者在Circulation(2篇)、Eur Heart J、Nat Neurosci、J Clin Invest等著名期刊发表学术论文15篇。

演讲题目:一碳代谢异常致先天性心脏病的分子机理。

代表性论文和专著:

1.Jian-Yuan Zhao, Bin Qiao, Wen-Yuan Duan, Xiao-Hong Gong, Qian-Qian Peng, Song-Shan Jiang, Chen-Qi Lu, Yi-Jiang Chen, Hong-Bing Shen, Guo-Ying Huang, Li Jin, Hong-Yan Wang. Genetic variants reducing MTR gene expression increase risk of congenital heart disease in Han Chinese population. European Heart Journal 2014, 35: 733-742. (2013 IF=14.7)

2.Ji-Tian Xu*, Jian-Yuan Zhao*(Co-first author), Xiuli Zhao*, Davinna Ligons, Vinod Tiwari, Fidelis E. Atianjoh, Chun-Yi Lee, Lingli Liang, Weidong Zang, Dolores Njoku, Srinivasa N. Raja, Myron Yaster, Yuan-Xiang Tao. Morphine tolerance and hyperalgesia mediated through μ opioid receptor-triggered mTORC1 activation in dorsal horn neurons. The Journal of Clinical Investigation 2014, 124(2): 592-603. (2013 IF=13.8)

3.Xiuli Zhao*, Zongxiang Tang*, Hongkang Zhang*, Fidelis E. Atianjoh*, Jian-Yuan Zhao* (Co-first author), Lingli Liang, Wei Wang, Xiaowei Guan, Sheng-Chin Kao, Vinod Tiwari, Yong-Jing Gao, Paul N. Hoffman, Hengmi Cui, Min Li, Xinzhong Dong, Yuan-Xiang Tao. A native long noncoding RNA contributes to neuropathic pain by specifically silencing Kv1.2 in primary afferent neurons. Nature Neuroscience 2013, 16(8): 1024-31. (2013 IF=15.0)

4.Jian-Yuan Zhao, Xue-Yan Yang, Kai-Hu Shi, Shu-Na Sun, Jia Hou, Zhi-Zhou Ye, Jue Wang, Wen-Yuan Duan, Yi-Jiang Chen, Hong-Bing Shen, Guo-Ying Huang, Li Jin, Hong-Yan Wang. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research 2013, 23: 242-253. (2013 IF=12.0)

5.Jian-Yuan Zhao, Xue-Yan Yang, Xiao-Hong Gong, Zhuo-Ya Gu, Wen-Yuan Duan, Jue Wang, Zhi-Zhou Ye, Hong-Bin Shen, Kai-Hu Shi, Jia Hou, Guo-Ying Huang, Li Jin, Bin Qiao, Hong-Yan Wang. A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population. Circulation 2012, 125(3): 482-90. (2013 IF=15.0)


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