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2017-08-10至2017-08-11 中国杭州
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任进 研究员

中国科学院上海药物研究所

天然药物衍生物的系统毒理学研究和应用

任进 研究员

演讲题目:天然药物衍生物的系统毒理学研究和应用

中国科学院上海药物研究所

个人简介:中国医科大学毕业,医学博士,在日本、美国学习工作15年。作为中科院百人计划受聘者,回国承担新药非临床GLP安全性评价和毒理学机制研究工作已经十余年,带领团队率先获得美国FDA/英国MHRA/OECD多个国家药物非临床安评GLP资格认证,已成为国家新药创制重大专项标志性成果。为国内外制药企业完成了数百项新药安评项目,支持申报中国、美国、欧洲IND承担了国家地方等多项课题。已在国内外著名杂志上发表了100余篇文章,申请了10项专利。被聘为多个学会的理事及杂志的编委。获得英国皇家病理学院Fellow和国际毒性病理学院Fellow的资格。作为第一完成人荣获国家科技进步二等奖、“中国药学会科学技术奖一等奖”2项,荣获“何粱何利基金科学与技术进步奖(医学药学奖)”等多项国家和地方的荣誉和奖励。

代表论著:

(2009.1.1-) 
1. Jun YAO1, Cheng-gang LI1, Li-kun GONG1, Chen-chen FENG1,Chun-zhu LI1, Man GAO1, Yang LUAN1, Xin-ming QI1,*, Jin REN1,*. Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice. Acta Pharmacologica Sinica, 2014, 35(2):292-300. (IF=2.354)

2. Guo C, He L, Yao D, A J, Cao B, Ren J, Wang G, Pan G. Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes. Toxicology Letters. 2014, 224(1):93-100. (IF=3.666)

3. Xin-ming QI 1,ǂ, Ling-ling MIAO1,ǂ, Yan CAI1 , Li-kun GONG1, *, Jin REN 1, *. ROS generated by Cyp450, especially Cyp2e1, mediated mitochondrial dysfunction induced by tetrandrine in rat hepatocytes. Acta Pharmacologica Sinica 2013; 34:1229-1236 . (IF=2.354)

4. Xiaofeng Xie 1, ǂ , Lingling Miao1, ǂ, Jun Yao 1, Chenchen Feng 1, Chenggang Li1, Man Gao 1, Mingxia Liu1, Likun Gong 1, Yizheng Wang2, Xinming Qi 1, *, Jin Ren 1, *. Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver. Drug Metabolism and Disposition, 2013; 41(10):1732-1737. (IF=3.361)

5. Cheng Y, Liu Y, Wang H, Li J, Ren J, Zhu L, Gong L*. A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats. J Ethnopharmacol. 2012,145(1):85-93. (IF=3.014)

6. Wu M, Xing G, Qi X, Feng C, Liu M, Gong L, Luan Y, Ren J. Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice. Mutat Res. 2012; 748(1-2): 65-9. (IF=3.035)

7. Luan Y, Xing G, Qi X, Wu M, Li C, Yao J, Gong L, Nohmi T, Gu J, Zhou W, Zheng S, Ren J. The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis. Arch Toxicol. 2012; 86(11): 1753-61. (IF=4.674)

8. Wu, Y., Qi, X., Gong, L., Xing, G., Xue, X., Li, Y., Chen, M., Yao, J., Miao, L., Luan, Y*. and Ren, J*. Identification of BC005512 as a DNA Damage Responsive Murine Endogenous Retrovirus of GLN Family Involved in Cell Growth Regulation. Plos one. 2012;7(4):e35010 (IF=4.411)

9. Luan Y, Kogi M, Rajaguru P, Ren J, Yamaguchi T, Suzuki K, Suzuki T. Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells. Mutat. Res.-Fundam. Mol. Mech. Mutagen. 2012, 1;731(1-2):20-6. (IF=3.556)

10. Guozhen Xing1,2, Xinming Qi1, Min Chen1,2, Yuanfeng Wu1,2, Jun Yao1,2, Likun Gong1, Takehiko Nohmi3,Yang Luan1*, and Jin Ren1* . Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012(743):52-58.(IF=3.035)

11. Xue X, Gong LK, Maeda K, Luan Y, Qi XM, Sugiyama Y, Ren J. Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I. Molecular Pharmaceutics 2011,8(6):2183-92. (IF=5.40)

12. Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G,Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicological Sciences. 2011,122(2):288-96. (IF=5.093)

13. Xia Liu, Xiang Xue, Likun Gong, Xinming Qi, Yuanfeng Wu, Guozhen Xing, Yang Luan, Ying Xiao, Xiongfei Wu, Yan Li, Min Chen, Lingling Miao, Jun Yao, Jun Gu, Donghai Lin, Jin Ren. 1H NMR-Based Metabolomic Analysis of Triptolide-Induced Toxicity in Liver-Specific Cytochrome P450 Reductase Knockout Mice. Metabolomics 2012(8):907-918. (IF=3.608)

14. Xiang Xuea, Likun Gonga*, Xinming Qia, Yuanfeng Wua, Guozhen Xinga, Jun Yaoa,Yang Luana, Ying Xiaoa, Yan Lia, Xiongfei Wua, Min Chena, Jun Gub, and Jin Rena, *. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicol Lett. 2011,205(1):47-54. (IF= 3.581)

15. Yan Li, Yang Luan, Xinming Qi, Zhi Chen, Ming Li1, Xia Liu, Likun Gong, Xiang Xue, Yuanfeng Wu, Min Chen, Guozhen Xing, Xiongfei Wu, Lingling Miao, Jun Yao , Jin Ren. Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicological Sciences 2010(118(2)): 435–443(IF= 5.093)

16. Yan Li, Xin-ming Qi, Xiang Xue, Xiong-fei Wu, Yuan-feng Wu, Min Chen, Guo-zhen Xing, Yang Luan and Jin Ren. The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury. Toxicology Letters . 2009,186(2):111-4 (IF= 3.581)


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