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2017-08-10至2017-08-11 中国杭州
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徐宏喜 院长

上海中医药大学中药学院

中药研发与国际化进展

徐宏喜 院长

演讲题目:中药研发与国际化进展

上海中医药大学中药学院

个人简介:徐宏喜教授,现为上海中医药大学首席教授、博士生导师、上海中医药大学中药学院院长。国家中组部“千人计划”特聘教授,上海市首批特聘专家。兼任中华中医药学会中药实验药理学分会主任委员;上海市药学会中药专业委员会主任委员;世界中医药协会联合会中药分析专业委员会副会长;世中联中药鉴定专业委员会副会长;全国中医药高等教育学会中药教育研究会第三届理事会副理事长;国际现代化中医药学术会议联席主席;上海市侨界知识分子联谊会第八届理事会常务理事及国际国内十余种学术刊物的编委等。1994年获得日本富山医科药科大学国立和汉药研究所药学博士学位。并于新加坡国立大学化学系及加拿大Dalhousie大学微生物学系进行博士后研究工作。曾先后受聘于香港中文大学中药研究中心科学主任、香港和记黄埔(中国)有限公司副总经理兼高级医药顾问,上海和黄药业有限公司董事兼研究开发总监。2001至2010年,担任香港赛马会中药研究院副总裁兼中药研究室主任。徐教授至今已发表SCI论文200多篇。H指数为43,入选2014年及2015年中国高被引用学者榜。拥有1项PCT专利以及6项美国专利。主要研究领域包括中药活性成分及药效评价研究,中药新药开发以及中药质量控制分析方法研究等。重点进行病毒、肿瘤、耐药菌及糖尿病等重大疾病的中药防治与药效评价研究,阐明中药药效物质基础及作用机制,研发具有自主知识产权的创新药物。


主要研究论文


1. M.H.Feng, B.Q.Tang, N.Z.Wang, H. X. Xu, X.F.Jiang, Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids, Angewandte Chemie (International ed. in English), 54(49), 14960-4 (2015). (IF=11.709)

2. G. Lin, J. Y. Wang, N. Li, M. Li, H. Gao, Y. Ji, F. Zhang, H. L. Wang, Y. Zhou, Y. Ye, H. X. Xu, J. Zheng, Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum, Journal of Hepatology, 54(4), 666-673 (2011). (IF=10.59)

3. Y. Z. Lao, G. Wan, Z. Y. Liu, X. Y. Wang, P. Ruan, W. Xu, D. Q. Xu, W. D. Xie, Y. Zhang, H. X. Xu, N. H. Xu, The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation, Autophagy, 10(5): 1-14 (2014). (IF= 9.108)

4. G. Wan, W. D. Xie, Z. Y. Liu, W. Xu, Y. Z. Lao, N. Huang, K. Cui, M. J. Liao, J. He, Y. Y. Jiang, Burton B Yang, H. X. Xu, N. H. Xu, Y. Zhang, Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway, Autophagy, 10(1): 70-79 (2014). (IF= 9.108)

5. H. L. Zhao, Y. Sui, C. F. Qiao, K. Y. Yip, R. K. K. Leung, S. K. W. Tsui, H. M. Lee, H. K. T. Wong, X. Zhu, J. J. Siu, L. He, J. Guan, L. Z. Liu, H. X. Xu, P. C. Y. Tong, J. C. N. Chan, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression, Diabetes, 61(4), 933-943 (2012). (IF=8.784)

6. Y. Liao, X. Liu, J. Yang, Y.Z. Lao, X.W.Yang, X.N.Li, J.J.Zhang, Z.J.Ding, H. X. Xu and G. Xu, Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile, Organic Letters, 17 (5), 1172–1175(2015). (IF=6.732)

7. Q. B. Han, T. F. Tso, S. Cheung, Tai, J. Z. Song, C. F. Qiao, H. D. Sun, and H. X. Xu, Maoecrystal Z, a Cytotoxic Diterpene from Isodon eriocalyx with an Unique Skeleton, Organic Letters, 8 (21), 4727-4730 ( 2006). (IF=6.732)

8. X. W. Yang, X. Deng, X. Liu, C. Y. Wu, X. N. Li, B. Wu, H. R. Luo, Y. Li, H. X. Xu, Q. S. Zhao, G. Xu, Hypercohin A, a new polycyclic polyprenylated acylphloroglucinols possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens, Chemical Communications, 48: 5998-6000 (2012). (IF=6.567)

9. L.Zhang, J.L.Feng, S.Y.Kong, M.Wu, Z.C.Xia, B.J.Zhang, W.W.Fu, Y.Z.Lao, H.S.Tan, H. X. Xu.Nujiangexathone A, a novel compound from Garcinia nujiangensis,suppresses cervical cancer growth by targeting hnRNPK, Cancer letters, 380(2):447-456 (2016).(IF=5.992)

10. T. W. D. Chan, P. P. H. But, S. W. Cheng, I. M. Y. Kwok, F. W. Lau, H. X. Xu, Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS, Analytical Chemistry, 72(6), 1281-1287 (2000). (IF=5.886)

11. K.K. Shen, J.L.Xie, H. Wang, H.Zhang, M.Y.Yu, F.F. Lu, H.S. Tan, H. X. Xu, Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells, Molecular Cancer Therapeutics, 14(7):1738-1749. (2015). (IF=5.579)

12. W. L. Ting Kan, C. Yin, H. X. Xu, G. Xu, K. K. W. To, C. H. Cho, J. A. Rudd, G. Lin, Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1 cell cycle arrest and apoptosis, International Journal of Cancer, 132(3): 707-716 (2013). (IF=5.531)

13. C. Feng, L. Y. Zhou, T. Yu, G. Xu, H. L. Tian, J. J. Xu, H. X. Xu, K. Q. Luo, A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation, International Journal of Cancer, 131(6): 1445-1454 (2012). (IF=5.531)

14. Z.C.Xi, M.Yao, Y.Li, C.L.Xie, J. Holst, T. Liu, S.F.Cai, Y.Z.Lao, H.S.Tan, H. X. Xu and Q.H. Dong, Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation, Cell Death & Disease, 7(6):e2252 (2016). (IF=5.378)

15. X.Y. Wang, Y. Z. Lao, N.H. Xu, Z.C. Xu, M. Wu, H. Wang, X. Li, H.S. Tan, M.H. Sun, H. X. Xu, Oblongifolin C inhibits metastesis by up-regulating keratin 18 and tubulins, Scientific Reports, 5:10293-10305. (2015). (IF=5.228)

16. Y.Lu, S.F.Cai, J.Nie, Y.Y. Li, G.C.Shi, J.M.Hao, W.W.Fu, H.S.Tan, S.L.Chen, B. Li, H. X. Xu ,The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma, Biochemical Pharmacology, 100:61-72(2015). (IF=5.091)

17. K.K.Shen, F.F.Lu, J.L.Xie, M.F.Wu, B.Cai, Y.R.Liu, H.Zhang, H.S.Tan, Y.Y.Pan, H. X. Xu.Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics, Oncotarget, doi: 10.18632/oncotarget.10585. [Epub ahead of print] (2016). (IF=5.008)

18. K.K.Shen, Z.C.Xi, J.L.Xie, H.Wang, C.L.Xie, C.S.Lee, P. Fahey, Q.H.Dong, H. X. Xu.Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1, Oncotarget, in press, (2016). (IF=5.008)

19. M.J.Wang, Q. Dong, H. Wang, Y.Q. He, Y.Chen, H.Zhang, R.Wu, X.C.Chen, B.P.Zhou, J.He, H.F.Kung, C.H.Huang, Y.Q.Wei, J.D.Huang, H. X. Xu, M.L.He, Oblongifolin M, an active compound isolated from a Chinese medical herb Garcinia oblongifolia, potently inhibits enterovirus 71 reproduction through downregulation of ERp57, Oncotarget, 7(8):8797-808. (2016). (IF=5.008)

20. Z.J.Ding, Y.Z.Lao, H.Zhang, W.W.Fu, L.L.Zhu, H.S.Tan, H. X. Xu, Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer, Oncotarget, 12;7(2):1826-37 (2015) (IF=5.008)

21. X. H. Pang, J. Y. Song, Y. J. Zhu, H. X. Xu, L. F. Huang, S. L. Chen, Applying plant DNA barcodes for Rosaceae species identification, Cladistics, 27(2), 165-170 (2011). (IF=4.952)

22. Y. W. Zhang, P. P. H. But, V. E. C. Ooi, H. X. Xu, G. D. Delaney, S. H. S. Lee, S. F. Lee,  Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin–carbohydrate complex from Prunella vulgaris, Antiviral Research, 75 (3), 242-249 (2007). (IF=4.909)

23. H. X. Xu, S. H. S. Lee, S. F. Lee, R. L. White, J. Blay, Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris, Antiviral Research, 44(1), 43-54 (1999). (IF=4.909)

24. Kurokawa, H. Ochiai, K. Nagasaka, H. X. Xu, S. Kadota, T. Namba, and K. Shiraki, Antiviral traditional medicines against herpes simplex virus, poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV infection in mice, Antiviral Research, 22, 175-188 (1993). (IF=4.909)

25. H.He, L.S.Ding, H. X. Xu, X.X.Lei, H.P.Xiao, Y.Zhou,Gymnothelignans A-O: Conformation and Absolute Configuration Analyses of Lignans Bearing Tetrahydrofuran from Gymnotheca chinensis,Journal of Organic Chemistry, 77(19): 8435-8443 (2012). (IF=4.785)

26. H.Zhang, D. Zheng,H.H. Li,H.Wang,H.S.Tan, H. X. Xu, Diagnostic filtering to screen polycyclic polyprenylated acylphloroglucinols from Garcinia oblongifolia by ultrahigh performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry, Analytica Chimica Acta,912:85-96. (2015).(IF=4.712)

27. Y. Zhou, N. Li, F. F. K. Choi, C. F. Qiao, J. Z. Song, S. L. Li, X. Liu, Z. W. Cai, P. P. Fu, G. Lin, H. X. Xu, A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry, Analytica Chimica Acta, 681(1-2), 33-40 (2010). (IF=4.712)

28. Y. Zhou, Stephanie Lee, Franky F. K. Choi, G. Xu, X. Liu, J. Z. Song, S. L. Li, C. F. Qiao, H. X. Xu, Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Analytica Chimica Acta, 678(1), 96-107 (2010). (IF=4.712)

29. Y. Zhou, X. Liu, J. Yang, Q. B. Han, J. Z. Song, S. L. Li, L. S. Ding, H. X. Xu, Analysis of caged xanthones from the resin of Garcinia hanburyi using ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Analytica Chimica Acta, 629, 104-118 (2008). (IF=4.712)

30. X. J. Zhang, Z. Li, W. M. Leung, L. Liu, H. X. Xu, Z. X. Bian, The Analgesic Effect of Paeoniflorin on Neonatal Maternal Separation-Induced Visceral Hyperalgesia in Rats, Journal of Pain, 9 (6), 497-505 (2008). (IF=4.463)

31. H. Y. Qin, J. C. Y. Wu, X. D. Tong, J. J. Y. Sung, H. X. Xu, Z. X. Bian, Systematic review of  animal models of post-infectious/post-inflammatory irritable bowel syndrome. Journal of Gastroenterology, 46(2), 164-174 (2011). (IF=4.414)

32. Z. X. Bian, Z. Li, Z. X. Huang, M. Zhang, H. L. Chen, H. X. Xu, J. J. Y. Sung, Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients, Journal of Gastroenterology, 44(7), 666-674 (2009). (IF=4.414)

33. L. T. Yi, Y.C. Li, Y. Pan, J. M. Li, Q. Xu, S. F. Mo, C. F. Mo, F. X. Xu, H. X. Xu, X. B. Lu, L. D. Kong, H. F. Kung, Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 15; 32(2), 510-519 (2008). (IF=4.361)

34. X. J. Zhang, F. F. K. Choi, Y. Zhou, F. P. Leung, S. Tan, S. H. Lin, H. X. Xu, W. Jia, J. J. Y. Sung, Z. W. Cai, Z. X. Bian, Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics: A pilot study, FEBS Journal, 279(13): 2322-2338 (2012). (IF=4.237)

35. X. Wang, Y. C. Chen, Q. B. Han, C. Y. Chan, H. Wang, Z. Liu, C. H. K. Cheng, D. T. Yew, M. C. M. Lin, M. L. He, H. X. Xu, J. J. Y. Sung, H. F. Kung, Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma, Proteomics, 9(2), 242-253 (2009). (IF=4.079)

36. H. S. Tan, D. D. Hu, J. Z. Song, Y. Xu, S. F. Cai, Q. L. Chen, Q. W. Meng, S. L. Li, S. L. Chen, Q. Mao, H. X. Xu, Distinguishing Radix Angelica sinensis from different regions by HS-SFME/GC-MS,  Food chemistry, 186:200-206 (2015) (IF=4.052)

37. B. Xia, Y. Zhou, H. S. Tan, L. S. Ding, H. X. Xu, Advanced ultra-performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometric methods for simultaneous screening and quantification of triterpenoids in Poria cocos, Food Chemistry, 152: 237-244 (2014). (IF=4.052)

38. Q. B. Han, T. Yu, F. Lai, Y. Zhou, C. Feng, W. N. Wang, X. H. Fu, C. B. S. Lau, K. Q. Luo, H. X. Xu, H. D. Sun, K. P. Fung, P. C. Leung, Quick identification of apoptosis inducer from Isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection, Talanta, 82(4), 1521-1527 (2010). (IF=4.035)

39. Q. B. Han, Y. K. Yip, N. Y. Yang, L. Wong, C. F. Qiao, J. Z. Song, H. Yiu, H. X. Xu, Rapid analysis of pseudolaric acids in Cortex Pseudolaricis and related medicinal products by high performance liquid chromatography, Talanta, 73(4), 757-763 (2007). (IF=4.035)

40. M.S. Liu, L.Tao, S. L. Chow, R. Wu, H. Zhang, Y.F.Yang, D.J.Yang, Z.X.Bian, A.P.Lu, Q.B.Han, H. X. Xu, Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: finding anti-enterovirus 71 agents from Anemarrhena asphodeloide., Journal of Chromatography A, 1368:116-124 (2014). (IF=3.926)

41. S. L. Li, H. Shen, L. Y. Zhu, J. Xu, X. B. Jia, H. M. Zhang , H. X. Xu, G. Lin, H. Cai, B. C. Cai, S. L. Chen, Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical  transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng, Journal of Chromatography A, 1231: 31-45 (2012). (IF=3.926)

42. Y. Zhou, J. Z. Song, Franky F. K. Choi, H. F. Wu, C. F. Qiao, L. S. Ding, S. L. Gesang, H. X. Xu, An experimental design approach using response surface techniques to obtain optimal liquid chromatography and mass spectrometry conditions to determine the alkaloids in Meconopsi species, Journal of Chromatography A, 1216 (42), 7013-7023 (2009). (IF=3.926)

43. J. Z. Song, C. F. Qiao, S. L.  Li, Y. Zhou, M. T. Hsieh, H. X. Xu, Rapid optimization of dual-mode gradient high performance liquid chromatographic separation of Radix et Rhizoma Salviae Miltiorrhizae by Response Surface Methodology, Journal of Chromatography A, 1216 (42), 7007-7012 (2009). (IF=3.926)

44. Y. Zhou, G. Xu, F. F. K. Choi, L. S. Ding, Q. B. Han, J. Z. Song, C. F. Qiao, Q. S. Zhao, H. X. Xu, Qualitative and quantitative analysis of diterpenoids in Salvia species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 1216 (24), 4847-4858 (2009). (IF=3.926)

45. C. Y. Li, H. X. Xu, Q. B. Han, T. S. Wu, Quality assessment Radix Codonopsis by quantitative nuclear magnetic resonance, Journal of Chromatography A, 1216(11), 2124-2129 (2009). (IF=3.926)

46. Y. Zhou, Q. B. Han, J. Z. Song, H. X. Xu, Characterization of polyprenylated xanthones in Garcinia xipshuanbannaensis using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 1206 (2), 131-139 (2008). (IF=3.926)

47. Q. B. Han, J. Z. Song, C. F. Qiao, L. Wong, and H. X. Xu, Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography, Journal of Chromatography A, 1127(1-2), 298-301 (2006). (IF=3.926)

48. S. B. Chen, H. P. Liu, R. T. Yian, D. J. Yang, S. L. Chen, H. X. Xu, A. S. C. Chan, and P. S. Xie, High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. Journal of Chromatography A, 1121(1), 114-119 (2006). (IF=3.926)

49. Y. Xie, Z. H. Jiang, H. Zhou, H. X. Xu, and L. Liu, Simultaneous determination of six Aconitum alkaloids in proprietary Chinese medicines by high-performance liquid chromatography, Journal of Chromatography A, 1093 (1-2), 195-203 (2005). (IF=3.926)

50. J. Z. Song, H. X. Xu, S. J. Tian, and P. P. H. But, Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis, Journal of Chromatography A, 857, 303-311(1999). (IF=3.926)

51. W. M. Fu, J. F. Zhang, H. Wang, Z.C. Xi, W.M. Wang, P. Zhuang, X. Zhu, S.C. Chen, T. M. Chan, K. S. Leung, G. Lu, H. X. Xu, H. F. Kung, Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma, Journal of Proteomics, 75(15): 4833-4843 (2012). (IF=3.867)

52. L. Z. Liu, S. C. K. Cheung, L. L. Lan, S. K. S. Ho, H. X. Xu, J. C. N. Chan, P. C. Y. Tong, Berberine modulates insulin signaling transduction in insulin-resistant cells, Molecular and Cellular Endocrinology, 317 (1-2), 148-153 (2010). (IF=3.859)

53. Y.X.Tang, W.W.Fu, R.Wu, H.S.Tan, Z.W.Shen, H. X. Xu.Bioassay-Guided Isolation of Prenylated Xanthone Derivatives from the Leaves of Garcinia oligantha, Journal of Natural Products, 79(7):1752-61 (2016).(IF=3.662)

54. H. Zhang, D. D. Zhang, Y. Z. Lao, W. W. Fu, S. Liang, Q. H. Yuan, L. Yang, and H. X. Xu, Cytotoxic and Anti-inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta, Journal of Natural Products, 77:1700-1707 (2014). (IF=3.662)

55. H. Zhang, L. Tao, W. W. Fu, S. Liang, Y. F. Yang, Q. H. Yuan, D. J. Yang, A. P. Lu, H. X. Xu, Prenylated benzoylphloroglucinols and xanthones from the leaves of Garcinia oblongifolia with antienteroviral activity, Journal of Natural Products, 77:1037-1046(2014). (IF=3.662)

56. C. Feng, S. X. Huang, X. M. Gao, H. X. Xu, Kathy Luo, Characterization of proapoptotic compounds from the bard of Garcinia oblongifolia, Journal of Natural Products. 77:1111-1116 (2014). (IF=3.662)

57. Z. X. Xia, D. D. Zhang, S. Liang, Y. Z. Lao, H. Zhang, H. S. Tan, S. L. Chen, X. H. Wang, H. X. Xu. Bioassay-Guided Isolation of Prenylated Xanthones and Polycyclic Acylphloroglucinols from the Leaves of Garcinia nujiangensis,Journal of Natural Products. 75(8): 1459-1464 (2012). (IF=3.662)

58. X. Liu, T. Yu, X. M. Gao, Y. Zhou, C. F. Qiao, Y. Peng, S. L. Chen, Kathy Q. Luo, H. X. Xu, Apoptosis effects of Polyprenylated Benzoylphloroglucinol Derivatives from the Twigs of Garcinia multiflora, Journal of Natural Product, 73(8),1355-1359 (2010). (IF=3.662)

59. G. Xu, W. L. T. Kan, Y. Zhou, J. Z. Song, Q. B. Han, C. F. Qiao, C. H. Cho, J. A. Rudd, G. Lin, H. X. Xu, Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa, Journal of Natural Product, 73(2), 104-108 (2010). (IF=3.662)

60. S. X. Huang, C. Feng, Y. Zhou, G. Xu, Q. B. Han, C. F. Qiao, D. C. Chang, K. Q. Luo, H. X. Xu, Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia, Journal of Natural Product, 72 (1), 130-135 (2009). (IF=3.662)

61. R. W. Jiang, J. R. Zhou, P. M. Hon, S. L. Li, Y. Zhou, L. L. I, W. C. Ye, H. X. Xu, P. C. Shaw, P. P. But, Lignans from Dysosma versipellis with Inhibitory Effects on Prostate Cancer Cell Lines, Journal of Natural Product, 70 (2), 283-286 (2007). (IF=3.662)

62. R. W. Jiang, P. M. Hon, Y. Zhou, Y. M. Chan, Y. T. Xu, H. X. Xu, H. Greger, P. C. Shaw, P. P. H. But, Alkaloids and Chemical Diversity of Stemona tuberose, Journal of Natural Product, 69(5), 749-754 (2006). (IF=3.662)

63. H. Dong, S. X. Chen, R. M. Kini, H. X. Xu, Effects of Tannins from Geum japonicum on the Catalytic Activity of Thrombin and Factor Xa of Blood Coagulation Cascade, Journal of Natural Product, 61(11), 1356-1360 (1998). (IF=3.662)

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75. Ruby L. C. Hoo, Janice Y. L. Wong, C. F. Qiao, A. Xu, H. X. Xu, Karen S. L. Lam, The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, Nutrition & Metabolism, 7, 67 (2010). (IF=3.28)

76. X.Li, Y.Z.Lao, H.Zhang, X.Y.Wang, H.S.Tan, Z.X.Lin, H. X. Xu,The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation, BMC Cancer,15:254-266, (2015).(IF=3.265)

77. S. D. Qi, S. L. Tian, H. X. Xu, J. J. Y. Sung, Z. X. Bian, Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection, Analytical and Bioanalytical Chemistry, 393 (8), 2059-2066 (2009). (IF=3.125)

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