学术会议:紧随研究趋势 洞察学术热点 进入>
产业会议:新技术,新领域,深入产业环节 进入>
举办会议及论坛超过百场 邀请海内外院士超过50名 教授PI专家授课超过1000名 总参会人数超过10万人
Menu
报名参会

已确认嘉宾Normal Guest

许执恒 研究员

中科院遗传与发育研究所

许执恒 研究员

个人简介:许执恒博士,中科院遗传发育所研究员,1989年毕业于上海第二军医大学,1999年获美国新泽西Rutgers大学博士学位。1999-2005在美国哥伦比亚大学神经生物学和精神病中心/病理系做博士后及高级研究助理。先后获得美国NIH的 Ruth L. Kirschstein National Research Service Award (2002-03)及Rutgers大学Bush Fellowship (1997-1999)和Waksman Fellowship (1993-1997),2006年中国科学院“百人计划”入选者,2007年国家杰出青年科学基金获得者。课题组利用在信号转导领域的优势,结合基因操作小鼠模式动物,从事多种疾病(小头畸形,精神分裂症,自闭症和神经退行性疾病)的病理机制研究。争取在阐明不同的重要疾病发生的分子机制方面有所突破,为疾病的预防和治疗提供理论依据,同时为个体正常发育的分子机理提供新见解。以通信作者身份发表28篇论文包括Cell Stem Cell, Nat. Commun (2篇), Cell Reports (2篇),Hepatology, Cell Research (3篇) 和 Blood。

演讲题目:大脑发育与相关疾病的发病机制研究。

主要论著目录 (* Corresponding author)

 

1.Li C, Xu D, .. Xu Z*.   (2016) Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell doi:10.1016/j.stem.2016.04.017

 

2.Zhang HS…. Xu Z*.  (2016) Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat. Commun. doi: 10.1038/ncomms11773.

 

3.Zhang F. Yu JW, Yang T. Xu D,.Xia YH., Xu Z*. (2016) A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Biol Chem pii: jbc.M116.716811. (Cover story, “Paper of the week” with editorial comments)

 

4.Xu D. and Xu Z*. (2016) Driving WDR62 to the Pole. Cell Cycle DOI:10.1080/15384101. 2016.1154374


5. Li P… Xu Z*, and Zhu Z*. Epigenetic silencing of microRNA-149 in cancer associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment Cell Research (accepted)


6. Zhang F. Xu D,. Sun YM., Xu Z*. Epigenetic regulation of Atrophin1 by lysine-specific demethylase is required for cortical progenitor maintenance. Nat. Commun, 5:5815. doi: 10.1038/ncomms6815


7. Xu D. Zhang F, Wang Y, Sun Y, Xu Z*. (2014) Microcephaly Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the developmental cortex. Cell Reports 6(1):104-16


8. Yu J, Zhang F, Zhang Y, Fan M and Xu Z* (2014) TAK1 is activated by TGF-β signaling and controls axonal growth during brain development. JMCB 6(4):349-51.


9. Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z. (2014) BMP2-SMAD Signaling Represses the Proliferation of Embryonic Neural Stem Cells through YAP. J Neuroscience 34(36):12039-48


10. Zhu Y, Wang C, Yu M, and Xu Z*. (2013) ULK1 and JNK are Involved in Mitophagy Incurred by LRRK2 G2019S Expression. Protein Cell 4(9): 711-21.


11. Shi W, Chen Y, Gan G, Ren J, Wang Q, Xu Z, Xie X, and Zhang Y. (2013) Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression. J Neuroscience 24;33(30):12352-63.


12. Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. (2013) HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. PNAS 19;110(12):4604-9.


13. Yang T., Sun YM…Xu Z* (2012) POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration. Cell Reports 2(3):640-51 (Article).


14. Wilhelm M, Kukekov NV, Schmit TL, Biagas KV, Sproul AA, Gire S, Maes ME, Xu Z, Greene LA.(2012)Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem287(3):2247-56.


15. J Niu, M Yu and Z Xu*. (2012) Leucine-Rich Repeat Kinase 2 (LRRK2) Disturbs Mitochondrial Dynamics via Dynamin-Like Protein (DLP1). J NeuroChem 122(3):650-8.

16. J Cui, M Yu, Z Xu* (2011). Expression of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibits the Processing of uMtCK to Induce Cell Death in cell culture model system. Biosci Rep 31(5):429-437.


17. Y Sun, T Fei, T Yang, F Zhang, Y Chen, Z Xu* (2010) The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 285(50): 39039–39050.


18. Ren J., Wang Y., Liang Y....and Xu Z(2010) Methylation of ribosomal protein s10 by protein arginine methyltransferase 5 regulates ribosome biogenesis J Biol Chem. 285(17):12695-705.


19. C Wang, Y Tao, Y Wang, Z Xu* Regulation of the Protein Stability of POSH and MLK Family. Protein Cell 1(9): 871–878.

20. Y Sun, Z Xu* (2010) Regulation of Neural Stem Cell by Bone Morphogenic Protein (BMP) Signaling During Brain Development. Frontiers in Biology 5(5):380-385.

21. B Lu; Y Zhai, C Wu; X Pang, Z Xu, F Sun (2010) Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2. BBA-Proteins and Proteomics 804(9):1780-4.


22. M Zhang, Y Zhang and Z Xu* (2010) POSH is Involved in Egr-Bsk (TNF-JNK) Signaling and Embryogenesis in Drosophila. J Genetics and Genomics 37(9):605-19.


23. Shen Q, Qin F, Gao Z, Cui J, Xu Z, and Yang C, (2009) Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegansMol Cell Biol, 29(14): 3881–3893.


24. Jin S, Pan L, Liu Z, Wang Q, Xu Z, and Zhang Y (2009) Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136(9):1571-81.


25. Sproul A Xu Z and Greene L (2009) Cbl Negatively Regulates JNK Activation and Cell Death. Cell Research 19(8):950-61.


26. Liu S, Yu M, He Y, Xiao L,…, and Xu Z* (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 47(6) 1964-73.


27. Qiao HX, Hao CJ, Li Y, He X, Chen RS, Cui J, Xu Z*, Li W*.(2008) JNK activation mediates the apoptosis of xCT-deficient Cells. BBRC 370(4):584-8.


28. Sun Y, Yang T, Xu Z* (2007) The JNK Pathway and Neuronal Migration. J Genetics and Genomics 34(11): 957-965.


29. Wilhelm M, Kukekov NV, Xu Z, Greene LA (2007) Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH. Dev Neurosci. 29(4-5):355-62.


30. Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. (2007) Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon Cancer Cells. Cancer Res. 67(10):4700-4708.


31. Cui J, Zhang M, Zhang YQ, Xu Z* (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacol Sin. 28(5):601-8.


32. Welhelm M, Xu Z., and Greene L (2007)Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. J Biol Chem. 282(2):1288-95.


33. Xu Z.*, Sproul A., Wang WY, and Greene L. (2006) SIAH1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis. J Biol Chem. 281(1):303-12.

(* Corresponding author)


34. Kukekov, N*.,Xu Z.*, and Greene(2006) Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. J Biol Chem. 281(22):15517-24.

(* Equal contribution)


35. Tang G, Xu Z, Goldman JE. (2006) Synergistic effects of the SAPK/JNK & the proteasome pathways on GFAP accumulation in Alexander disease. J Biol Chem. 281(50):38634-43.


36. Xu Z.*, Kukekov, N., and Greene L (2005) A stability-based self-amplifying feed forward loop mechanism for regulation of the apoptotic JNK pathway. Mol Cell Biol. 25(22):9949-59.

(* Corresponding author)


37. Xu Z.* and Greene L. (2006) Regulation of the apoptotic JNK pathway. Methods Enzymol 406:479-89. (* Corresponding author)


38. Zheng S.*, Xu Z.*¨, and Longey J. (2005) Cbl-b/Cbl regulates c-Kit receptor stability through the proteasomal pathway in mast cells. Blood 105(1):226-32. (* Equal contribution, ¨ Corresponding author).


39. Hanlon SE, Xu Z, Norris DN, Vershon AK. (2004) Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae. Yeast. 21(15):1241-52.


40. Kim K., Kim B., Xu Z, and Kim S. (2004). Mixed lineage kinase (MLK) 3-activated p38 MAP kinase mediates TGF-Beta-induced apoptosis in hepatoma cells. J Biol Chem. 279(28):29478-84.


41. Xu Z., Kukekov N., and Greene LA (2003). POSH (plenty of SH3’s) Acts as a Scaffold for a Multiprotein Complex that Mediates JNK Activation in Apoptotic Death. EMBO J 15; 22(2): 252-61.


42. Xu Z, Maroney AC, Dobrzanski P, Greene LA (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol. 21(14): 4713-24.


43. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL (2001). Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 276(27): 25302-8.


44. Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA (2001). beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem. 77(1):157-64.


45. Xu Z., and Norris D. (1999). The SFP1 gene product of S. cerevisiae regulates G2/M transitions in the mitotic cell cycle and in response to DNA damage. Genetics 150(4): 1419-28.


邀请函

下载邀请函
大会咨询
姓名 *

E-mail*

电话: *

消息: *

×
留下姓名电话和邮箱,邀请函直接发送到邮箱
*姓名:
* 电话:
* Email: