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赵庆顺 教授

南京大学模式动物研究所

赵庆顺 教授

个人简介:赵庆顺,1987年本科毕业于南京大学,获学士学位;1990年硕士研究生毕业于南京大学,获硕士学位;1990-1996年任教于南京大学。2001年博士研究生毕业于普度大学,获博士学位。2001-2003年在杜克大学医学中心从事博士后研究。2002年受聘于南京大学,任副教授;2006年晋升为教授,2006.6-现在 南京大学 模式动物研究所 教授 (2007年4月起聘为博导) 研究方向:以模式动物斑马鱼为研究对象,运用基因组改造手段(转基因和基因敲除),研究遗传和环境因素调控脊椎动物胚胎早期发育包括胚层形成和分化、胚胎体轴建立及心血管发生的分子机制。2.以土著水产经济动物黄颡鱼为研究对象,通过实验动物化研究,建立代表我国土著水生脊椎动物的模式动物体系;运用基因组改造手段(转基因和基因敲除),开展经济水生动物的分子辅助育种研究。

演讲题目:斑马鱼心脏瓣膜发生受环境和遗传因素的双重调控。

论文:

1.   Shu Xu, Shasha Cao, Bingjie Zou, Yunyun Yue, Chun Gu, Xin Chen, Pei Wang, Xiaohua Dong, Zheng Xiang, Kai Li, Minsheng Zhu**, Qingshun Zhao**, Guohua Zhou*. (2016) An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome Biology. 17(1):186. doi: 10.1186/s13059-016-1038-5.

2.   Junbo Li, Yunyun Yue, Qingshun Zhao*. 2016. Retinoic acid signaling is essential for valvulogenesis by affecting endocardial cushions formation in zebrafish embryos. Zebrafish,  13(1):9-18. (Cover)

3.   Jingyun Li, Yunyun Yue, Xiaohua Dong, Wenshuang Jia, Kui Li, Dong Liang, Zhangji Dong, Xiaoxiao Wang, Xiaoxi Nan, Qinxin Zhang, Qingshun Zhao*. 2015. Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. The Journal of Biological Chemistry, 290(16):10216-28.

4.   Zhangji Dong, Xiaohua Dong, Wenshang Jia, Shasha Cao, Qingshun Zhao*. 2014.  Improving the efficiency for generation of genome-edited zebrafish by labelling primordial germ cells. The International Journal of Biochemistry & Cell Biology, 55:329-34.

5.   Jingyun Li, Kui Li, Xiaohua Dong, Dong Liang, Qingshun Zhao*. 2014. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis. Developmental Dynamics, 243(12):1544-1553.

6.   Junbo Li, Wenshuang Jia, Qingshun Zhao*. 2014. Nitrite affects zebrafish valvulogenesis through yielding too much NO signalling. PLoS ONE, 9(3):e92728.

7.   Zhangji Dong, Jiachun Ge, Zhiqiang Xu, Xiaohua Dong, Shasha Cao, Jianlin Pan,Qingshun Zhao*. 2014. Generation of myostatin b knock out yellow catfish (Tachysurus fulvidraco) using transcription activator-like effector nucleases. Zebrafish, 11(3):265-74.

8.   Ting Xu, Jing Zhao, Ping Hu, Zhangji Dong, Jingyun Li, Hongchang Zhang, Daqiang Yin*, Qingshun Zhao**. 2014. Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage. Toxicology and Applied Pharmacology, 277(2):183-91.

9.   Dong Liang, Wenshuang Jia, Jingyun Li, Kui Li, Qingshun Zhao*. 2012. Retinoic acid signalling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS ONE, 7(2): e30865.

10. Jiachun Ge, Zhangji Dong, Jingyun Li, Zhiqiang Xu, Wei Song, Jie Bao, Dong Liang, Junbo Li, Kui Li, Wenshuang Jia, Muzi Zhao, Yongxiang Cai, Jiaxin Yang, Jianlin Pan, Qingshun Zhao*. 2012. Isolation of yellow catfish b-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein. Transgenic Research, 21(5):995-1004.

11. Jingyun Li, Ping Hu, Kui Li, Qingshun Zhao*. 2012. Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter. The Anatomical Record, 295:268-277.

12. Zhangji Dong, Jiachun Ge, Kui Li, Zhiqiang Xu, Dong Liang, Jingyun Li, Junbo Li, Wenshuang Jia, Yuehau Li, Xiaohua Dong, Shasha Cao, Xiaoxiao Wang, Jianlin Pan,Qingshun Zhao*. 2011. Heritable targeted inactivation of myostatin gene in yellow catfish (Pelteobagrus fulvidraco) using engineered zinc finger nucleases. PLoS ONE, 6(12):e28897.

13. Fang Xu, Kui Li, Miao Tian, Ping Hu, Wei Song, Jiong Chen, Xiang Gao, Qingshun Zhao*. 2009. N-CoR is required for patterning the anterior–posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mechanism of Development, 126:771-780.

14. Daqiang Yin, Hankai Zhu, Ping Hu, Qingshun Zhao*. 2009. Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver. Environmental Toxicology and Chemistry, 28(3): 603–608.

15. Ping Hu, Miao Tian, Jie Bao, Guangdong Xing, Xingxing Gu, Xiang Gao, Elwood Linney,Qingshun Zhao*. 2008. Retinoid regulation of the zebrafish cyp26a1 promoter. Developmental Dynamics, 237:3798-3808.

16. Dong Liang, Mei Zhang, Jie Bao, Luqing Zhang, Xiaofeng Xu, Xiang Gao, Qingshun Zhao*. 2008. Expressions of Raldh3 and Raldh4 during zebrafish early development. Gene Expression Patterns, 8(4): 248-253.

17. Jianlin Pan, Xiaolin Wang, Wei Song, Jianxiu Chen, Caojun Li, Qingshun Zhao*. 2007. Molecular cloning and expression pattern of myostatin gene in yellow catfish (Pelteobagrus fulvidraco). DNA Sequence, 18 (4): 279-287.

18. Xingxing Gu, Fang Xu, Wei Song, Xiaolin Wang, Ping Hu, Yumin Yang, Xiang Gao,Qingshun Zhao*. 2006. A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid. Molecular Endocrinology, 20(7):1661-1672.

19. Daqiang Yin, Ying Gu, Yan Li, Xiaolin Wang, Qingshun Zhao*. 2006. Pentachlorophenol treatment in vivo elevates point mutation rate in zebrafish p53 gene. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 609:92-101.

20. Wei Song, Zhiying Zou, Fang Xu, Xingxing Gu, Xiaofeng Xu, Qingshun Zhao*. 2006. Molecular cloning and expression of a second zebrafish aldehyde dehydrogenase 2 gene (aldh2b). DNA Sequence, 17(4):262-269.

21. Lu Sun, Zhiying Zou, Paul Collodi, Fang Xu, Xiaofeng Xu, Qingshun Zhao*. 2005. Identification and characterization of a second fibronectin gene in zebrafish. Matrix Biology, 24(1): 69-77.

22. Xingxing Gu, Fang Xu, Xiaolin Wang, Xiang Gao, Qingshun Zhao*. 2005. Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gene Expression Patterns, 5(6):733-739. .


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