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2017-11-03至2017-11-04 北京大成路9号
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夏建川 主任

中山大学肿瘤防治中心

夏建川 主任

中山大学肿瘤防治中心

夏建川 医学博士、教授、博士生导师现任中山大学附属肿瘤医院生物治疗中心主任、体细胞治疗与保健研究中心主任 医学博士、博士生导师,中华医学生物免疫学会主任委员,中国细胞治疗质量控制和研究专业委员会主任委员,广东省细胞生物学学会理事长,广东省抗癌协会生物治疗专业委员会主任委员,国家食品和药品监督管理局新药评审专家,美国《Cancer Letter》杂志编委,《癌症》杂志常务编委。2000-2003年在哈佛大学Dana-Farber肿瘤研究所从事肿瘤的免疫治疗和肿瘤疫苗的研究。在此期间,首次证实DC/肿瘤融合细胞疫苗能诱导自发性乳腺癌转基因小鼠产生抗肿瘤免疫应答,为DC/肿瘤融合细胞疫苗在临床治疗肿瘤中的应用奠定了基础。2004年6月回国,积极开展肿瘤体细胞免疫治疗的基础和临床应用研究,在国内率先建立了体细胞制备技术操作规范、体细胞临床应用安全检测标准和体细胞免疫治疗临床应用规范,使体细胞免疫治疗向规范道路上迈出了重要的一步, 近5年来在肿瘤病因学和肿瘤免疫治疗领域发表SCI收入的研究论文50余篇。主编了国内第一部《肿瘤生物治疗基础与临床应用》 的教材(中国科技出版社2011年8月出版);获得三项国家发明专利。曾获得省政府科技进步二等奖,2008年首届广州新侨留学生回国创业贡献奖,享受国家政府特殊津贴。

演讲题目:原发性肝癌个体化治疗模式的探讨。

发表论文

1.

Lu L, Tao H, Chang AE, Hu Y, Shu G, Chen Q, Egenti M, Owen J, Moyer JS, Prince ME, Huang S, Wicha MS, Xia JC(Corresponding), Li Q. Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells. Oncoimmunology. 2015 Jan 9.

2.Pan QZ, Wang QJ, Dan JQ, Pan K, Li YQ, Zhang YJ, Zhao JJ, Weng DS, Tang Y, Huang LX, He J, Chen SP, Ke ML, Chen MS, Wicha MS, Chang AE, Zeng YX, Li Q, Xia JC(Corresponding). A nomogram for predicting the benefit of adjuvant cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma.Sci Rep.2015 Mar 17.

3.Zhang XF,Pan QZ,Pan K,Weng DS,Wang QJ,Zhao JJ,He J,Liu Q,Wang DD,Jiang SS,Zheng HX,Lv L,Chen CL,Zhang HX,Xia JC(Corresponding). Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma. Mol Carcinog. 2015 Jan 3.

4.Pan QZ, Pan K, Wang QJ, Weng DS, Zhao JJ, Zheng HX, Zhang XF, Jiang SS, Lv L, Tang Y, Li YQ, He J, Liu Q, Chen CL, Zhang HX, Xia JC(Corresponding). Annexin A3 as a Potential Target for Immunotherapy of Liver Cancer Stem‐Like Cells. Stem Cells. 2015 Feb;33(2):354-66.

5.Jiang SS, Weng DS, Wang QJ, Pan K, Zhang YJ, Li YQ, Li JJ, Zhao JJ, He J, Lv L, Pan QZ, Xia JC(Corresponding). Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinoma. J Transl Med. 2014 Sep 27;12(1):273.

6.Chao J, Zhang XF, Pan QZ, Zhao JJ, Jiang SS, Wang Y, Zhang JH, Xia JC(Corresponding). Decreased expression of TRIM3 is associated with poor prognosis in patients with primary hepatocellular carcinoma. Med Oncol. 2014 Aug;31(8):102.

7.Mai C, Zhao JJ, Tang XF, Wang W, Pan K, Pan QZ, Zhang XF, Jiang SS, Zhao BW, Li YF, Xia JC(Corresponding), Zhou ZW. Decreased ITIH5 expression is associated with poor prognosisin primary gastric cancer. Med Oncol.2014 Jul;31(7);53.

8.Pan K, Wang QJ, Liu Q, Zheng HX, Li YQ, Weng DS, Li JJ, Huang LX, He J, Chen SP, Ke ML, Zeng YX, Xia JC(Corresponding). The phenotype of ex vivo generated cytokine-induced killer cells is associated with overall survival in patients with cancer. Tumour Biol 2014;35(1): 701-7.

9.Wang H, Jiang S, Zhang Y, Pan K, Xia JC(Corresponding), Chen M. High expression of thymosin beta 10 predicts poor prognosis for hepatocellular carcinoma after hepatectomy. World J Surg Oncol  2014 Jul 18;12:226.

10.Zhao JJ, Pan QZ, Pan K, Weng DS, Wang QJ, Li JJ, Lv L, Wang DD, Zheng HX, Jiang SS, Zhang XF, Xia JC(Corresponding).Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells. Sci Rep.2014 Jun 5;4:5177.

11.Zheng Y, Wang DD, Wang W, Pan K, Huang CY, Li YF, Wang QJ, Yuan SQ, Jiang SS, Qiu HB, Chen YM, Zhang XF, Zhao BW, Mai C, Xia JC(Corresponding), Zhou ZW. Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients. PLoS One.2014 Apr 3;9(4):e93073.

12.Pan K, Guan XX, Li YQ, Zhao JJ, Li JJ, Qiu HJ, Weng DS, Wang QJ, Liu Q, Huang LX, He J, Chen SP, Ke ML, Zeng YX,Xia JC(Corresponding).Clinical activity of adjuvant cytokine-induced killer cell (CIK) immunotherapy in patients with post-mastectomy triple-negative breast cancer patients.Clin CancerRes.2014 Jun 1;20(11):3003-11.

13.Keshari RP,Wang W,Zhang Y,Wang DD,Li YF,Yuan SQ,Qiu HB,Huang CY,Chen YM,Xia JC (Corresponding),Zhou ZW.Decreased Expression of the GATA3 Gene Is Associated with Poor Prognosis in Primary Gastric Adenocarcinoma.PLoS One.2014 Feb 4;9(2):e87195

14.Pan K, Lv L, Zheng HX, Zhao JJ, Pan QZ, Li JJ, Weng DS, Wang DD, Jiang SS, Chang AE, Li Q, Xia JC(Corresponding). OK-432 synergizes with IFN-γ to confer dendritic cells with enhanced antitumorimmunity. Immunol Cell Biol.2014 Mar;92(3):263-74.

15.Wang SH, Lu L, Fan Y, Wicha MS, Cao Z, Chang AE, Xia JC, Baker JR Jr, Li Q.Characterization of a novel transgenic mouse tumor model for targeting HER2+ cancer stem cells.Int J Biol Sci.2013 Dec 6;10(1):25-32.

16.Pan QZ, Pan K, Weng DS, Zhao JJ, Zhang XF, Wang DD, Lv L, Jiang SS, Zheng HX, Xia JC(Corresponding). Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma. Mol Carcinog.2013 Dec 23.

17.Yang XB, Zhao JJ, Huang CY, Wang QJ, Pan K, Wang DD, Pan QZ, Jiang SS, Lv L, Gao X, Chen HW, Yao JQ, Zhi M, Xia JC (Corresponding). Decreased Expression of the FOXO3a Gene Is Associated with Poor Prognosis in Primary Gastric Adenocarcinoma Patients. PLoS One. 2013 Oct 230;8(10): e78158

18.Pan QZ, Pan K, Zhao JJ, Chen JG, Li JJ, Lv L, Wang DD, Zheng HX, Jiang SS, Zhang XF, Xia JC (Corresponding). Decreased expression of interleukin-36α correlates with poor prognosis in hepatocellular carcinoma. Cancer Immunol Immunother. 2013 Sep 6.

19.Lu L, Pan K, Zheng HX, Li JJ, Qiu HJ, Zhao JJ, Weng DS, Pan QZ, Wang DD, Jiang SS, Chang AE, Li Q, Xia JC (Corresponding). IL-17A promotes immune cell recruitment in human esophageal cancers and the infiltrating dendritic cells represent a positive prognostic marker for patient survival. J Immunother. 2013 Oct;36(8):451-8.

20.Huang CY, Zhao JJ, Lv L, Chen YB, Li YF, Jiang SS, Wang W, Pan K, Zheng Y, Zhao BW, Wang DD, Chen YM, Yang L, Zhou ZW, Xia JC (Corresponding). Decreased Expression of AZGP1 Is Associated with Poor Prognosis in Primary Gastric Cancer. PLoS One. 2013 Jul 23;8(7):e69155.

21.Pan K, Li YQ, Wang W, Xu L, Zhang YJ, Zheng HX, Zhao JJ, Qiu HJ, Weng DS, Li JJ, Wang QJ, Huang LX, He J, Chen SP, Ke ML, Wu PH, Chen MS, Li SP, Xia JC (Corresponding), Zeng YX. The Efficacy of Cytokine-Induced Killer Cell Infusion as an Adjuvant Therapy for Postoperative Hepatocellular Carcinoma Patients.Ann Surg Oncol. 2013 Jul 27.

22.Huang ZM, Li W, Li S, Gao F, Zhou QM, Wu FM, He N, Pan CC, Xia JC, Wu PH, Zhao M. Cytokine-induced killer cells in combination with transcatheter arterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma patients. J Immunother. 2013 Jun;36(5):287-93.

23.Zhang F, Sun XF, Li YQ, Zhen ZJ, Zheng HX, Zhu J, Wang QJ, Lu SY, He J, Wang J, Pan K, Cai RQ, Chen Y, Weng DS, Sun FF, Xia JC (Corresponding). Safety of in vitro amplified HLA-haploidentical donor immune cell infusions for childhood malignancies. Chin J Cancer. 2013 May 27. doi: 10.5732 / cjc.012.10298.

24.Zhao JJ, Pan K, Wang QJ, Xu ZD, Weng DS, Li JJ, Li YQ, Xia JC (Corresponding). Effect of anti-asthma Chinese medicine Chuankezhi on the anti-tumor activity of cytokine-induced killer cells.Chin J Cancer.2013 Mar 8. doi: 10.5732/cjc.012.10249.

25.Huang CY, Chen YM, Zhao JJ, Chen YB, Jiang SS, Yan SM, Zhao BW, Pan K, Wang DD, Lv L, Li YF, Wang W, Zhou ZW, Xia JC (Corresponding).Decreased expression of transcription elongation factor a-like 7 is associated with gastric adenocarcinoma prognosis. PLoS One. 2013;8(1):e54671.

26.Li JJ, Shan HB, Xu GL, He LJ, Xia JC. Submucosal saline solution injection combined with endosonography for distinguishing between stages T1aand T1b of early esophageal cancer. Gastrointest Endosc.2013 Jan;77(1):159-60.

27.Li JJ, Pan K, Gu MF, Chen MS, Zhao JJ, Wang H, Liang XT, Sun JC, Xia JC (Corresponding). Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma. Chin J Cancer. 2013 Mar;32(3):141-8.

28.Li YF, Wang DD, Zhao BW, Wang W, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC (Corresponding), Zhou ZW. High Level of COP1 Expression is Associated with Poor Prognosis in Primary Gastric Cancer. Int J Biol Sci. 2012;8(8):1168-77.

29.Li YF, Wang DD, Zhao BW, Wang W, Yuan SQ, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC (Corresponding), Zhou ZW. Poor prognosis of gastric adenocarcinoma with decreased expression of AHRR. PLoS One. 2012;7(8):e43555.

30.Wang DD, Chen YY, Pan K, Wang W, Chen SP, Chen JG, ZhaoJJ, Lv L, Pan QZ, Li YQ, Wang QJ, Huang LX, Ke ML, He J, Xia JC (Corresponding). Decreased Expression of the ARID1A Gene Is Associated with Poor Prognosis in Primary Gastric Cancer. PLoS One. 2012; 7(7): e40364

31.Zhao JJ, Pan K, Wang W, Chen JG, Wu YH, Lv L, Li JJ, Chen YB, Wang DD, Pan QZ, Li XD, Xia JC (Corresponding). The prognostic value of tumor-infiltrating neutrophils in gastric adenocarcinoma after resection.PLoS One.2012;7(3):e33655.

32.Li JJ, Gu MF, Pan K, Liu LZ, Zhang H, Shen WX, Xia JC (Corresponding).Autologous Cytokine-Induced Killer Cell Transfusion in Combination with Gemcitabine plus Cisplatin Regimen Chemotherapy for Metastatic Nasopharyngeal Carcinoma. J Immunotherapy. 2012 Feb-Mar;35(2):189-95.

33.Pan K, Liang XT, Zhang HK, Zhao JJ, Wang DD, Li JJ, Lian Q, Chang AE, Li Q, Xia JC (Corresponding).. Characterization of BIN1 as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma. Mol Med. 2012 18:507-18.

34.Chen Y, Pan K, Li S, Xia J (Corresponding), Wang W, Chen J, Zhao J, Lü L, Wang D, Pan Q, Wang Q, Li Y, He J, Li Q. Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer. J Surg Oncol. 2012 Sep 1;106(3):286-93.

35.Zhao JJ, Pan K, Li JJ, Chen YB, Chen JG, Lv L, Wang DD, Pan QZ, Chen MS, Xia JC (Corresponding). Identification of LZAP as a New Candidate Tumor Suppressor in Hepatocellular Carcinoma. PLoS One. 2011; 6(10): e26608.

36.Wang W, Lv L, Pan K, Zhang Y, Zhao JJ, Chen JG, Chen YB, Li YQ, Wang QJ, He J, Chen SP, Xia JC (Corresponding). Reduced expression of transcription factor AP-2α is associated with gastric adenocarcinoma prognosis. PLoS One. 2011; 6(9): e24897.

37.Lv L, Pan K, Li XD, She KL, Zhao JJ, Wang W, Chen JG, Chen YB, Yun JP, Xia JC (Corresponding). The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma. PLoS One. 2011; 6(3): e18219.

38.Liang XT, Pan K, Chen MS, Li JJ, Wang H, Zhao JJ, Sun JC, Chen YB, Ma HQ, Wang QJ, Xia JC (Corresponding). Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma. J Gastroenterol Hepatol. 2011; 26(3): 544-9

39.Ma H, Liang X, Chen Y, Pan K, Sun J, Wang H, Wang Q, Li Y, Zhao J, Li J, Chen M, Xia J (Corresponding). Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma. Int J Cancer. 2011; 128(4): 771-7.

40.Chen JG, Xia JC (Corresponding), Liang XT, Pan K, Wang W, Lv L, Zhao JJ, Wang QJ, Li YQ, Chen SP, He J, Huang LX, Ke ML, Chen YB, Ma HQ, Zeng ZW, Zhou ZW, Chang AE, Li Q. Intratumoral Expression of IL-17 and Its Prognostic Role in Gastric Adenocarcinoma Patients. Int J Biol Sci. 2011; 7(1): 53-60.

41.Ma H, Weng D, Chen Y, Huang W, Pan K, Wang H, Sun J, Wang Q, Zhou Z, Wang H, Xia J (Corresponding). Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene. Mol Cancer. 2010; 9:190.

42.Pan K, Zhao JJ, Wang H, Li JJ, Liang XT, Sun JC, Chen YB, Ma HQ, Liu Q, Xia JC (Corresponding). Comparative analysis of cytotoxic T lymphocyte response induced by dendritic cells loaded with hepatocellular carcinoma -derived RNA or cell lysate. Int J Biol Sci. 2010; 6(7): 639-48.

43.Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (Corresponding). High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients. World J Gastroenterol. 2010; 16(36): 4611-5.

44.Wang QJ, Wang H, Pan K, Li YQ, Huang LX, Chen SP, He J, Ke ML, Zhao JJ, Li JJ, Sun JC, Liang XT, Ma HQ, Chen YB, Xia JC (Corresponding). Comparative study on anti-tumor immune response of autologous cytokine-induced killer (CIK) cells, dendritic cells-CIK (DC-CIK), and semi-allogeneic DC-CIK. Chin J Cancer. 2010; 29(7): 641-8.

45.Sun JC, Pan K, Chen MS, Wang QJ, Wang H, Ma HQ, Li YQ, Liang XT, Li JJ, Zhao JJ, Chen YB, Pang XH, Liu WL, Cao Y, Guan XY, Lian QZ, Xia JC (Corresponding). Dendritic cells-mediated CTLs targeting hepatocellular carcinoma stem cells. Cancer Biol Ther. 2010; 10(4): 368-75.

46.Ma H, Zhang Y, Wang Q, Li Y, He J, Wang H, Sun J, Pan K, Chen M, Xia J (Corresponding). Therapeutic safety and effects of adjuvant autologous RetroNectin activated killer cell immunotherapy for patients with primary hepatocellular carcinoma after radiofrequency ablation. Cancer Biol Ther. 2010; 9(11): 903-7.

47.Zhang H, Ma H, Wang Q, Chen M, Weng D, Wang H, Zhou J, Li Y, Sun J, Chen Y, Liang X, Zhao J, Pan K, Wang H, Xia J (Corresponding). Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array. Oncol Rep. 2010; 23(2): 445-55.

48.Zhou J, Weng D, Zhou F, Pan K, Song H, Wang Q, Wang H, Wang H, Li Y, Huang L, Zhang H, Huang W, Xia JC (Corresponding). Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses. Cancer Immunol. Immunother. 2009; 58(10): 1587-97.

49.Pan K, Wang H, Liu W, Zhang H, Zhou J, Li J, Weng D, Huang W, Sun J, Liang X, Xia JC (Corresponding). The pivotal role of p38 and NF-κB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432. Immunobiology 2009; 214(5): 350-358.

50.Zhang HK, Pan K, Wang H, Weng DS, Song HF, Zhou J, Huang W, Li JJ, Chen MS, Xia JC (Corresponding). Decreased Expression of Ing2 Gene and Its Clinicopathological Significance in Hepatocellular Carcinoma. Cancer Lett. 2008; 261(2): 183-192.

51.Weng DS, Zhou J, Zhou QM, Zhao M, Wang QJ, Huang LX, Li YQ, Chen SP, Wu PH, Xia JC (Corresponding). Minimally Invasive Treatment Combined with Cytokine-Induced Killer Cells Therapy Lower the Short-Term Recurrence Rates of Hepatocellular Carcinomas. J Immunother. 2008; 31(1): 63-71.

52.Ma HQ, Liang XT, Zhao JJ, Wang H, Sun JC, Chen YB, Pan K, Xia JC (Corresponding). Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma. World J Gastroenterol. 2009; 15(38): 4844-8.

53.Wang H, Pan K, Zhang HK, Weng DS, Zhou J, Li JJ, Huang W, Song HF, Chen MS, Xia JC (Corresponding). Increased Polycomb-Group Oncogene Bmi-1 Expression Correlates with Poor Prognosis in Hepatocellular Carcinoma. J Cancer Res Clin Oncol. 2008; 134(5): 535-541.

54.Pan K, Wang H, Chen MS, Zhang HK, Weng DS, Zhou J, Huang W, Li JJ, Song HF, Xia JC (Corresponding). Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2008; 134(11):1247-1253

55.Weng DS, Li JT, Mai SJ, Pan ZZ, Feng BJ, Feng QS, Huang LX, Wang QJ, Li YQ, Yu XJ, Chen SP, He J, Xia JC (corresponding). Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity. World J Gastroenterol. 2006; 12(15): 2437-2440.

56.Xia JC, Weng DS, Li JT, Qin HD, Mai SJ, Feng BJ, Fan Q, Feng QS, Huang LX, Yu XJ, Pan ZZ, Li YQ, Wang QJ, Zhan YQ, Chen SP, He J, Huang WL, Wu PH, Zeng YX. Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31. Cancer Genet Cytogenet. 2006; 166(2): 166-172.

57.Tanaka Y, Koido S, Xia JC(co-firster author), Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. Development of Antigen-Specific CD8+ Cytotoxic T Lymphocytes in MHC Class I-Deficient Mice through CD4 to CD8 Conversion. J Immunol. 2004; 172: 7848-7858.

58.Xia JC, Tanaka Y, Koido S, Liu C, Mukherjee P, Gendler SJ, Gong J. Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells. J Immunol. 2003; 170 (4): 1980-1986.


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