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2017-11-03至2017-11-04 北京大成路9号
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裴端卿 教授,院长

中科院广州生物与健康研究院

裴端卿 教授,院长

中科院广州生物与健康研究院

研究员、博士生导师,国家“863计划”生物医药领域专家, 国家中长期科技发展纲要“生殖与发育”重大研究计划专家,国家基金委杰出青年。

1984年毕业于华中农业大学,考入中美生物化学与分子生物学留学项目(CUSBEA 项目), 1985年赴美留学,1991年获得美国宾夕法尼亚大学分子细胞与发育专业博士学位。

1991年至2004年,先在美国密西根大学做博士后研究,美国明尼苏达大学药理系任助理教授、副教授;

2004年任中国科学院广州生物医药与健康研究院副院长,2008年6月任院长。

裴端卿的主要研究兴趣是干细胞的多能性维持与体细胞重编程,细胞内蛋白与膜运送机制;代表性学术成果发表在Nature,PNAS, JBC 等国际期刊上,共计50多篇论文,引用达2000余次;目前承担获国家自然科学基金重点项目,国家973项目,中科院知识创新基金多项; 担任生物化学杂志(Journal of Biological Chemistry)编委,细胞研究杂志(Cell Research)副主编,亚太干细胞网络执委,广州干细胞与再生医学技术联盟理事长。


主要发表论文:


Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H. Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions. Cell Stem Cell. 2017 Jan 11. pii: S1934-5909(16)30458-1.


Chen J, Pei D.Epigenetic Landmarks During Somatic Reprogramming. IUBMB Life. 2016 Nov;68(11):854-857.


Shu X, Pei D.Pluripotency without Proliferation. Cell. 2016 Feb 11;164(4):595-7.


Ying Z, Chen K, Zheng L, Wu Y, Li L, Wang R, Long Q, Yang L, Guo J, Yao D, Li Y, Bao F, Xiang G, Liu J, Huang Q, Wu Z, Hutchins AP, Pei D, Liu X.Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming. Cell Metab. 2016 Jan 12;23(1):220-6.


De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ.Hallmarks of pluripotency. Nature. 2015 Sep 24;525(7570):469-78.


Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D.The oncogene c-Jun impedes somatic cell reprogramming. Nat Cell Biol. 2015 Jul;17(7):856-67


Wu Y, Li Y, Zhang H, Huang Y, Zhao P, Tang Y, Qiu X, Ying Y, Li W, Ni S, Zhang M, Liu L, Xu Y, Zhuang Q, Luo Z, Benda C, Song H, Liu B, Lai L, Liu X, Tse HF, Bao X, Chan WY, Esteban MA, Qin B, Pei D.Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nat Cell Biol. 2015 Jun;17(6):715-25.


Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA.Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell. 2014 Nov 6;15(5):574-88


Zheng H, Hutchins AP, Pan G, Li Y, Pei D, Pei G.Where cell fate conversions meet Chinese philosophy. Cell Res. 2014 Oct;24(10):1162-3.


Hu X, Zhang L, Mao SQ, Li Z, Chen J, Zhang RR, Wu HP, Gao J, Guo F, Liu W, Xu GF, Dai HQ, Shi YG, Li X, Hu B, Tang F, Pei D, Xu GL.Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. Cell Stem Cell. 2014 Apr 3;14(4):512-22


Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, Wang X, Hu X, Gu T, Zhou Z, Liu J, Liu J, Wu H, Mao SQ, Mo K, Li Y, Lai K, Qi J, Yao H, Pan G, Xu GL, Pei D.Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet. 2013 Dec;45(12):1504-9.


Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D, Zheng H.Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol. 2013 Jul;15(7):829-38.


Song J, Zhong J, Guo X, Chen Y, Zou Q, Huang J, Li X, Zhang Q, Jiang Z, Tang C, Yang H, Liu T, Li P, Pei D, Lai L.Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs. Cell Res. 2013 Aug;23(8):1059-62.


Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D.A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Res. 2012 Feb;22(2):333-45.


Wang L, Wang L, Huang W, Su H, Xue Y, Su Z, Liao B, Wang H, Bao X, Qin D, He J, Wu W, So KF, Pan G, Pei D.Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods. 2013 Jan;10(1):84-9


Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, Liang H, Chen Y, Chen J, Wu Y, Guo L, Zhu J, Zhao X, Peng T, Zhang Y, Chen S, Li X, Li D, Wang T, Pei D.H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet. 2013 Jan;45(1):34-42.


Esteban MA, Pei D.Vitamin C improves the quality of somatic cell reprogramming. Nat Genet. 2012 Mar 28;44(4):366-7


Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA.Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Hum Mol Genet. 2012 Jan 1;21(1):32-45.


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