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张延 教授 研究员

上海交通大学系统生物医学研究院

张延 教授 研究员

学习工作经历:

       1986年毕业于山东大学微生物学专业
       1986 - 1989年在上海交通大学生物与技术系工作
       1993年和1996年分别获得日本东京大学应用生物工程专业硕士和博士学位
       1996-2006年先后在日本产业技术综合研究所(AIST),日本动物卫生研究所工作
       现为系统生物医学研究院糖生物学实验室课题组长。中日(SCSB-AIST)医学糖组学联合实验室中方主任

人才奖项:

       上海浦江人才(2007)

学会兼职:

       中国生物化学与分子生物学会糖复合物专业委员会常务委员
       中国蛋白质组学专业委员会委员
       亚洲糖组学研究联盟(ACGG)成员


演讲题目:新型血清糖链生物标志物WFA+-M2BP的临床应用意义


研究成果:

1.    Yu DM, Li XH, Mom V, Lu ZH, Liao XW, Han Y, Pichoud C, Gong QM, Zhang DH, Zhang Y, Deny P, Zoulim F, Zhang XX. N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape. Journal of hepatology. 2014 Mar;60(3):515-22. PubMed PMID: 24239777.

2.    Tan B, Matsuda A, Zhang Y, Kuno A, Narimatsu H. Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics. Molecular bioSystems. 2014 Feb;10(2):201-5. PubMed PMID: 24301485.

3.    Zou X, Feng B, Dong T, Yan G, Tan B, Shen H, Huang A, Zhang X, Zhang M, Yang P, Zheng M, Zhang Y*. Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. Journal of proteomics. 2013 Dec 6;94:473-85. PubMed PMID: 24332065.

4.    Zhu X, Gong Q, Yu D, Zhang D, Gu L, Han Y, Chen J, Zhang Y, Zhang X. Early serum hepatitis B virus large surface protein level: a stronger predictor of virological response to peginterferon alfa-2a than that to entecavir in HBeAg-positive patients with chronic hepatitis B. Journal of clinical virology. 2013 Aug;57(4):318-22. PubMed PMID: 23639294.

5.    Zhang X, Zhang Y*. Applications of azide-based bioorthogonal click chemistry in glycobiology. Molecules. 2013;18(6):7145-59. PubMed PMID: 23783454.

6.    Tan B, Qiu Y, Zou X, Chen T, Xie G, Cheng Y, Dong T, Zhao L, Feng B, Hu X, Xu LX, Zhao A, Zhang M, Cai G, Cai S, Zhou Z, Zheng M, Zhang Y*, Jia W*. Metabonomics identifies serum metabolite markers of colorectal cancer. Journal of proteome research. 2013 Jun 7;12(6):3000-9. PubMed PMID: 23675754.

7.    Aoki-Kinoshita K, Sawaki H, An H, Campbell M, Cao Q, Cummings R, Hsu D, Kato M, Kawasaki T, Khoo K, Kim J, Kolarich D, Li X, Liu M, Matsubara M, Okuda S, Packer N, Ranzinger R, Shen H, Shikanai T, Shinmachi D, Toukach P, Yamada I, Yamaguchi Y, Yang P, Ying W, Yoo J, Zhang Y, Zhang Y, Narimatsu H. The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository. Glycobiology. 2013;23(12):1422-4.

8.    Wang S, Xie W, Zhang X, Zou X, Zhang Y*. Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides. Chem Commun (Camb). 2012 Jun 14;48(47):5907-9. PubMed PMID: 22569546. 

9.    Li X, Wang J, Li W, Xu Y, Shao D, Xie Y, Xie W, Kubota T, Narimatsu H, Zhang Y*. Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases. Glycobiology. 2012 May;22(5):602-15. PubMed PMID: 22171061.

10.    Du D, Zhu X, Kuno A, Matsuda A, Tsuruno C, Yu D, Zhang Y, Ikehara Y, Tanaka Y, Zhang X, Narimatsu H. Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels. Clinica chimica acta; international journal of clinical chemistry. 2012 Nov 12;413(21-22):1796-9. PubMed PMID: 22796373.

11.    Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y*, Jia W*. Distinct urinary metabolic profile of human colorectal cancer. Journal of proteome research. 2012 Feb 3;11(2):1354-63. PubMed PMID: 22148915.

13.  王静,彭灿,张延*. O-糖基化起始糖基转移酶的活性与结构研究.生命科学,第23卷 第7期 2011年7月

14.    王胜,邹霞,张延*. 基于质谱的蛋白质O-糖基化分析. 化学进展,第22卷第12期2010年12月

15.  Peng C, Togayachi A, Kwon YD, Xie C, Wu G, Zou X, Sato T, Ito H, Tachibana K, Kubota T, Noce T, Narimatsu H, Zhang Y*. Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Biochemical and biophysical research communications. 2010 Nov 26;402(4):680-6. PubMed PMID: 20977886.

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