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罗永章 教授

清华大学抗肿瘤蛋白质药物国家工程实验室

罗永章 教授

学习经历:1981-1985 兰州大学化学系物理化学专业  学士                             

              1989-1993 美国加州大学伯克利分校分子与细胞生物学系生物化学专业  博士      

              1993-1994 美国哈佛大学医学院生物化学与分子药物学系   博士后      

              1994-1998 美国斯坦福大学医学院生物化学系  博士后      

               现任清华大学教授

主要科研领域与方向:

1. 肿瘤新生血管、新生淋巴管生成调控的分子机理

2. 肿瘤微环境与肿瘤转移的机理研究

3. 癌症的早期诊断

4. 阐明衰老、心血管疾病、阿兹海默症的机理

5. 从事蛋白质药物及诊断试剂的研发与转化

演讲题目:热休克蛋白90α(Hsp90α)是一个全新广谱肿瘤标志物


Selected Publications:

1. Shan Wang, Xin-an Lu, Peng Liu, Yan Fu, Lin Jia, Shunli Zhan & Yongzhang Luo (2015). “Endostatin Has ATPase Activity, Which Mediates Its Antiangiogenic and Antitumor Activities” Molecular cancer therapeutics. 14(5); 1192–201.

2. Hui Wang, Yang Chen, Xin-an Lu, Guanghua Liu, Yan Fu & Yongzhang Luo (2015). “Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis” Diabetes 64:2442–2456.

3. Jian Yang, Xiaomin Song, Yang Chen, Xin-an Lu, Yan Fu & Yongzhang Luo (2014). “PLCγ1–PKCγ Signaling-Mediated Hsp90α Plasma Membrane Translocation Facilitates Tumor Metastasis” Traffic. 15, 861-878.

4. Xin-an Lu, Xiaofeng Wang, Wei Zhuo, Lin Jia, Yushan Jiang, Yan Fu & Yongzhang Luo (2014). “The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation” Biochem. J. 457, 171–183.

5. Xiaofeng Wang, Xin’an Lu, Xiaomin Song, Wei Zhuo, Lin Jia, Yushan Jiang & Yongzhang Luo (2012). “Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery” Biochem. J. 441, 387-397.

6. Yan Fu & Yongzhang Luo (2010). “The N-terminal integrity is critical for the stability and biological functions of endostatin” Biochemistry 49, 6420–6429.

7. Xiaofeng Wang, Xiaomin Song, Wei Zhuo, Yan Fu, Hubing Shi, Yun Liang, Maomeng Tong, Guodong Chang & Yongzhang Luo (2009). “The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy” Proc. Natl. Acad. Sci. USA 106, 21288-21293.

8. Yujie Huang, Nan Song, Yanping Ding, Shaopeng Yuan, Xuhui Li, Hongchen Cai, Hubing Shi & Yongzhang Luo (2009). “Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis” Cancer Research 69, 7529-7537.

9. Hubing Shi, Yujie Huang, Hao Zhou, Xiaomin Song, Shaopeng Yuan, Yan Fu & Yongzhang Luo (2007). “Nucleolin is a receptor that mediates antiangiogenic and anti-tumor activity of endostatin” Blood (Featured in Cover) 110, 2899-2906. Comment on Shi et al, page 2899, by Judah Folkman (2007). “Endostatin finds a new partner: nucleolin” Blood 110, 2786-2787.

10. Yujie Huang, Hubing Shi, Hao Zhou, Xiaomin Song, Shaopeng Yuan & Yongzhang Luo (2006). “The angiogenesis function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin” Blood 107, 3564-3571.


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