Zhongjun Zhou is currently a professor at the School of Biomedical Sciences, The University of Hong Kong. He graduated from Xiamen University with a BSc in Biochemistry. He obtained Master of Science in Biochemistry and PhD in Pathophysiology from Peking Union Medical College. He also obtained a PhD degree in Medical Biochemistry from Karolinska Institute, Sweden. After postdoctoral training in in Karolinska Institute, he joined the department as a Research Assistant Professor in 2002 and became Associate Professor in 2005. He has published more than 40 original papers, reviews and book chapter. He is the co-founding Chair of Asian Association of Aging Research.
Aging, Chromatin Dynamics and Genomic maintenance
Stem cell self-renewal and differentiation in development,aging and cancer
Extracellular matrix and cell surface proteinases in regulation of growth factor signalling in development and diseases
1.H L Wong, G Jin, R Cao, S Zhang, Y Cao, Z Zhou*. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nature Communication 2015 (In press)
2.S Ghosh, B Liu, Y Wang, Q Hao, Z Zhou*. Lamin A is an endogenous SIRT6 activator and promote SIRT6-mediated DNA damage. Cell Reports 2015, 13 (6), 1396–1406
3.B Liu, Z Wang, L Zhang, S Ghosh, H Zheng and Z Zhou*. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nature Communication 2013; 4:1868.
4.B Liu, Z Wang and Z Zhou*.Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria. Aging Cell 2013; 12(2): 316-8.Epub 2012 Dec 21 | DOI: 10.1111/acel.12035)
5.B Liu, S Ghosh, X Yang, H Zheng, X Liu, Z Wang, B Zheng, B K Kennedy, Y Suh, M Kaeberlein, K Tryggvason, and Z Zhou*. Resveratrol rescues Sirt1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metabolism 2012, 16(6),738-750
6.K Chan, H Wong, G Jin, B Liu, R Cao, Y Cao, K Lehti, K Tryggvason and Z Zhou*. MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signalling in Calvarial Osteogenesis. Developmental Cell 2012, 22(6); 1176-1190 (Faculty 1000, F1000 Factor 8.0).
7.V Krishnan, M Z Chow, Z Wang, L Zhang, B Liu, X Liu and Z Zhou*. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc Natl Aca Sci USA 2011,108 (30);12325-12330.
8.G Jin, F Zhang, K M Chan, H L Wong, B Liu, K Cheah, X Liu, C Mauch, D Liu, Z Zhou*. MT1-MMP cleaves Dll1 to negatively regulate Notch signaling to maintain normal B cell development. EMBO J 2011, 30, 2281 – 2293