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童雪梅 教授

上海交通大学基础医学院

童雪梅 教授

童学梅,上海交通大学基础医学院博士生导师,生物化学与分子生物学专业

主要研究方向:研究细胞代谢的生物化学和分子生物学调控机制,以及在治疗癌症、脂肪肝和糖尿病等代谢性疾病中的应用。


学术论文:

1、Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.. Proc Natl Acad Sci U S A.,2012;109(18):6904-9 2、Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB. . Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha- induced metabolic reprogramming. . Oncogene.,2010;29(20):2962-72. 3、Tong X#, Zhao F, Thompson CB. . The molecular determinants of de novo nucleotide biosynthesis in cancer cells. . Current Opinion in Genetics & Development.,2009;19(1):32-7. 4、Tong X, Zhao F, Mancuso A, Gruber JJ and Thompson CB. . The glucose- responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. . Proc Natl Acad Sci U S A.,2009;106(51):21660-5. 5、Larouche D, Tong X, Fradette J, Coulombe PA, Germain L. . Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile. . FASEB J.,2008;22(5):1404-15. 6、Tong X, Coulombe PA. . Keratin 17 modulates hair follicle cycling in a TNFalpha- dependent fashion. . Genes & Development,2006;20(10):1353-64. 7、Tong X, Coulombe PA. . A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. . Journal of Investigative Dermatology,2004;122(4):965-70. 8、Tong X, Coulombe PA. . Mouse models of alopecia: identifying structural genes that are baldly needed.. Trends in Molecular Medicine,2003;9(2):79-84. 9、McGowan KW, Tong X*, Colucci-Guyon E, Langa F, Babinet C, Coulombe PA. . Keratin 17 null mice exhibit age- and strain-dependent alopecia. . Genes & Development,2002;16(11):1412-22.


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