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周大旺 教授/副院长

厦门大学生命科学学院

Hippo 信号通路与肿瘤发生

周大旺 教授/副院长

演讲题目:Hippo 信号通路与肿瘤发生

厦门大学生命科学学院

  周大旺,博士,厦门大学生命科学学院教授, 副院长。美国纽约市立大学硕士、爱因斯坦医学院博士、哈佛大学医学院博士后、哈佛大学医学院医学系讲师;获得国家首批"青年千人计划"资助、特聘为福建省“闽江学者”教授、入选国家杰青、中青年科技创新领军人才; 担任中国细胞生物学会发育生物学会副会长、国家千人计划联谊会生物医药专业委员会副主任和中国Hippo研究联盟的主要召集人之一,承担了多个CNS子刊的论文审稿。

长期从事Hippo信号通路在器官再生重塑与大小调控及肿瘤、免疫疾病发生的机制和功能研究, 近五年以通讯作者在Cancer CellScience Transl MedNat ImmunolNat CommunCell RepJ Exp Med等期刊上发表11篇,子刊6篇(2篇为封面文章)。


代表性论文(Selected Publications,*Corresponding author)


1.  Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH*, Deng X*,Zhou D*. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.Science Translational Medicine. 2016 ; 8(352):352ra108. doi: 10.1126/scitranslmed.aaf2304.(Cover Story)

2.  Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L*, Zhou D*.Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature Immunol. 2015. doi: 10.1038/ni.3268. (Cover Story)

3.  Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L*, Zhou D*. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nature Commun, 2015; 6:6239. doi: 10.1038/ncomms7239.  

4.  Wu H, Xiao Y, Zhang S, Ji S,Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C,      Lin J, Yin Z, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L*, Zhou D*. The Ets transcription factor GABP is a component of the Hippo pathway essential for growth and antioxidant defense. Cell Reports 2013; 3(5):1663-77. 

5.  Mou F, Praskova M, Xia F, Van Buren D, Hock H, Avruch, J*, Zhou D*. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med. 2012; 209(4):741-59.

6.  Zhou D*. Diversity in function and regulation of the Hippo pathway. Cell Biosci. 2013; 3(1):34.

7. Chen L, Qin F, Deng X, Avruch J, Zhou D*. Hippo pathway in intestinal homeostasis and tumorigenesis.Protein Cell. 2012; (4):305-10.

8.  Zhou D, Zhang Y, Wu H, Yi Y, Lawrence E, Dawson D,  Willis J,  Markowitz S, Camargo F,Avruch J*. The Mst1 and Mst2 kinases suppress intestinal stem cell proliferation and tumorigenesis by inhibiting Yap overabudance. Proc Natl  Acad  Sci  U S A. 2011; 108(49):E1312-20.

9. Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez R, Zhou D, Kreger B, Vasioukhin V, Avruch J, Brummelkamp T, Camargo F*. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell.2011; 144(5):782-95.

10.  Zhou D, Conrad C, Park J, Xia F, Payer B, Lauwers G, Thasler W, Lee J, Avruch J*, Bardeesy N*. Mst1 and Mst2 maintain hepatocyte quiescence and suppress the development of hepatocellular carcinoma through inactivation of Yap1 oncogene. Cancer Cell. 2009; 16: 425-38.  

11. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J*. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc  Natl  Acad  Sci  U S A. 2008; 105(51):20321-6.

 


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