The Role of E2F1 in Stem Cells Metabolism and Vascular Repair
Personal profile: Gangjian Qin, MD, FAHA, is Professor, Director of the Molecular Cardiology Program, at University of Alabama at Birmingham. He has recently moved from the Feinberg Cardiovascular Research Institute, Northwestern University, where he served for 9 years as assistant and tenured associate professor. Dr. Qin’s research program is dedicated to defining the molecular mechanisms that underlie cardiovascular biology and contribute to the recovery from cardiovascular disease, and to translating the results from these basic science investigations to clinical applications. A portion of his research focuses on the transcriptional networks and genetic pathways that control the growth and function of blood vessels. His lab for the first time described the roles of the E2F oncogenes in the ischemic angiogenesis and blood pressure regulation. Another focus of Dr. Qin’s research is to improve the reparative capacity of endogenous stem cells, including bone marrow stem cells and cardiac stem cells, for the treatment of ischemic heart disease. His work has contributed to the advancement of the field by characterizing the molecular interactions between bone marrow stem cells and their microenvironment and by establishing the significance of specific mobilization of stem cells in the ischemic tissue repair. Most recently, his group has revealed a pivotal role of oxidative metabolism in stem cell differentiation into vascular endothelial cells. Additionally, Dr. Qin’s lab has identified a unique population of cardiac stem cells in the rodent heart and systemically evaluated the impact of ischemia/hypoxia on their regenerative capacity. Other ongoing research in Qin lab includes epigenetic mechanisms of cardiac differentiation of embryonic and induced-pluripotent stem (ES and iPS) cells, development of peptide-based nanoparticles for enhancing the therapeutic benefit of human CD34+ cells in pre-clinical models, and novel signaling pathways linking adipogenesis and obesity. Dr. Qin has published over 90 original research articles in major international journals as well as numerous reviews, book chapters, and editorials. He serves on the editorial boards of 12 international journals in the fields of stem cell biology and cardiovascular sciences and as an expert reviewer for over 40 biomedical journals. Dr. Qin also serves in the review of grant applications for the NIH, VA, AHA, CASIS, and a number of international funding agencies. His research is continuously supported by NIH, AHA, and the American Diabetes Association (ADA).