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2017-12-08至2017-12-09 上海
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仇子龙 研究员

中科院上海神经科学研究所

仇子龙 研究员

中科院上海神经科学研究所

仇子龙研究员从事自闭症的神经生物学研究,研究工作主要集中在与自闭症及瑞特综合征等发育性神经系统疾病关系密切的基因Methyl-CpG binding protein 2 (MeCP2) 上,主要工作包括:1)发现MeCP2蛋白直接影响核内小RNA剪切加工复合物的活性而调控神经元内小RNA的产生,提出了发育性神经系统疾病致病机理的新观点(Cheng et al., Dev Cell, 2014),2)应用TALEN基因编辑方法得到敲除MECP2基因的食蟹猴,建立了食蟹猴基因编辑系统,为在非人灵长类中建立自闭症模型、深入研究自闭症的神经机理打下重要基础(Liu et al., Neurosci Bull, 2014),3)应用慢病毒转基因方法得到慢病毒介导的转基因方法成功获得了8只存活的携带人类MECP2基因的转基因食蟹猴,系统性的分析了MECP2转基因食蟹猴的行为表型,发现MECP2转基因食蟹猴表现出多种自闭症患者的症状如重复刻板行为、社交障碍及升高焦虑水平等,系首次建立精神疾病的基因工程非人灵长类动物模型,为自闭症的病理与转化研究提供重要动物模型(Liu et al., Nature, 2016)。

 

课题组受中科院战略先导计划,科技部973,基金委重大研究计划等项目资助。2014年入选中科院脑科学与智能技术卓越中心,2016年获中科院上海分院杰出青年科技创新人才奖,2016年获国家基金委杰出青年基金。 仇子龙研究员与复旦大学附属儿科医院,上海交大精神卫生中心,新华医院等建立了针对儿童自闭症的长期科研合作,积极开展中国自闭症的基础与临床的合作研究。他还长期致力于社会大众的自闭症与基因科学科普工作,与果壳网,知识分子等科普媒体有长期合作关系,撰写了大量自闭症方面的科普,并参加在中科院组织的科普活动,“科幻星云奖”,科幻苹果核,以及“一席”论坛等多次针对自闭症的科学普及报告,为普及科学知识做出了努力。


代表性论文:

1.Dang T, Duan W,Yu B, Tong DL,Cheng C, Zhang YF, Wu W, YeK, Zhang WX, WuM, WuBB, AnY, Qiu Z*,BL Wu*, (2017) Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development. Molecular Psychiatry doi:10.1038/mp.2016.253

2.Cheng TL.*, Chen J., Wan H., Tang B., Tian W., Liao L.*, Qiu Z.* (2017) Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain. Scientific Reports 7:42790. doi: 10.1038/srep42790

3.Chen Z, Li X, Zhou J, Yuan B, Yu B, Tong D, Cheng C, Shao Y, Xia S, Zhang R, Lyu J, Yu X, Dong C, Zhou WH, Qiu Z.*(2017)Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome.Scientific Reports.7:41701. doi: 10.1038/srep41701.

4.Yuan B, Cheng TL, Yang K, Zhang X, Qiu Z*. (2017) Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors. Journal of Genetics and Genomics. pii: S1673-8527(16)30153-9. doi: 10.1016/j.jgg.2016.10.004.

5.Liu, Z., Li, X., Zhang, J., Cai, Y., Cheng, T., Cheng, C., Wang, Y., Zhang, C., Nie, Y., Chen, Z., Bian, W., Zhang, L., Xiao, J., Lu, B., Zhang, Y., Zhang, X., Sang, X., Wu, J., Xu, X., Xiong, Z., Zhang, F., Yu, X., Gong, N., Zhou, W., Sun, Q.* & Qiu, Z.*(2016)Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature 530:98-102

6.Xin, Y., Yuan, B., Yu, B., Wang, Y., Wu, J., Zhou, W.*, Qiu, Z.* (2015) Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Scientific Reports 5:7645. doi: 10.1038/srep07645.

7.Liu, Z., Zhou, X., Zhu, Y., Chen, Z., Yu, B., Wang, Y., Zhang, C., Nie, Y., Sang, X., Cai, Y.,  Zhang, Y., Zhang, C., Zhou, W., Sun, Q.*, and Qiu, Z.* (2014) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci. Bull. 30: 381-386.

8.Cheng, T., Wang, Z., Liao, Q., Zhu, Y., Zhou, W., Xu, W., Qiu, Z.* (2014) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Dev. Cell  28:547-560.

9.Zhang, Y., Mao, R., Chen, Z., Tian, M., Tong, D., Gao, Z., Huang, M., Li, X., Xu, X., Zhou, W., Li, C., Wang, J., Xu, L.*, Qiu, Z.* (2014) Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Mol. Brain 7:11.

10.Cheng, J., Huang, M., Zhu, Y., Xin, Y., Zhao, Y., Huang, J., Yu, J., Zhou, W.*, and Qiu, Z.* (2013) SUMOylation of MeCP2 is essential for transcriptional rep ression and hippocampal synapse development. J. Neurochem. 128:798-806.

11.Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo,S., Yuan,Y., Oleksiak, A., Zhang, Y., Li, N.,  Hu, Y., Chen, W., Qiu, Z.*, Pääbo, S.*, Khaitovich, P.* (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 22:611-622

12.Qiu, Z., Sylwestrak, E., Lieberman, D., Zhang, Y., Liu, X., Ghosh A.* (2012) The Rett syndrome protein MeCP2 regulates synaptic scaling. J. Neurosci. 32:989-94.

13. Qiu, Z.*, and Cheng, J. (2010) The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond. Neurosignals 18: 72-81. (Invited review)

14. Qiu, Z., and Ghosh, A.* (2008). A Calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60: 775-787. (Highlighted in Molecular Biology Select of Leading Edge section on Cell at Jan. 29. 2009)

15. Qiu, Z., and Ghosh, A.* (2008). A brief history of neuronal gene regulation: regulatory mechanisms and cellular consequences. Neuron 60: 449-455. (Invited review)

16. Kashani, A. H., Qiu, Z., Jurata, L., Lee, S. K., Pfaff, S., Goebbels, S., Nave, K. A., and Ghosh, A.* (2006). Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J. Neurosci. 26: 8398-8408.

17. Qiu, Z., Wei, Y., Chen, N., Jiang, M., Wu, J.*, and Liao, K.* (2001). DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J. Biol. Chem. 276: 11988-11995.


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