学术会议:紧随研究趋势 洞察学术热点 进入>
产业会议:新技术,新领域,深入产业环节 进入>
举办会议及论坛超过百场 邀请海内外院士超过50名 教授PI专家授课超过1000名 总参会人数超过10万人
2017-12-08至2017-12-09 上海
Menu
报名参会
Sign up

大会主席CongressChairman

乐卫东 副院长/教授

大连医科大学/中科院上海生命科学院

乐卫东 副院长/教授

大连医科大学/中科院上海生命科学院

乐卫东,中组部千人计划特聘神经病学教授,中科院上海生命科学院-上海交通大学健康所研究员。大连医科大学附属第一医院副院长,辽宁省神经退行性疾病重点实验室主任,神经病学教授,博士生导师。乐卫东教授在美国贝勒医学院从事神经病学研究20余年,曾任美国休斯顿贝勒医学院神经病学教授,美国休斯顿贝勒医学院帕金森病研究中心主任,美国休斯顿贝勒医学院老年医学兼职教授.香港大学荣誉教授。 在多巴胺神经元发育基因调控,胚胎干细胞向多巴胺神经元定向分化的研究,神经退行性疾病统疾病的发病机制及帕金森病生物学标记及靶向治疗研究,蛋白质的降解与神经退行性疾病等方面取得国际公认的成就. 在《Nature Genetics》、《Science》《PNAS》、《J. Neuroscience》、《Brain》、《JAMA》、《Annals of Neurology》等国际重要学术杂志上发表SCI收录论文220余篇, 900余分,被引用近一万次。主编和参编专著10部,包括参加美国神经病学百科全书的编著。获得和在审专利八项。在美国获取23项国际研究基金资助,其中担任12项国际研究基金的首席科学家,包括3项NIH的RO-1研究基金。曾获1989年国家教委科学进步二等奖;1999年国际帕金森和运动障碍疾病协会大会奖;2002年美国神经科学大会奖;2008 美国Wistar Institute年度奖; 2008年中华医学科技二等奖; NIH, VA, INSERM,新加坡科学院基金和中国基金委和科技部重点项目, 杰青、长江、千人评审专家;担任了18家国际杂志的审委;Plos One, Journal of Alzheimer’s disease 杂志的副主编,Autophagy, Neurodeg Disease,CMJ,杂志的编委;在国际学术交流活动中,三次担任教育部“春晖计划”赞助的美国医学代表团团长; 1-5届中美21世纪医学论坛组委会美方主席;第一届和第二届世界医学高峰会秘书长,国际帕金森病联盟理事。在国际评估机构Elsevier最新发布的“2014年和2015年度神经科学领域“高被引”中国学者榜单名列第三位。


主要发表论文:


Zhang F, Zhong R, Li S, Chang RC, Le W.The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms. J Neural Transm (Vienna). 2017 Feb 10. doi: 10.1007/s00702-017-1696-9.


Yang J, Zhao H, Ma Y, Shi G, Song J, Tang Y, Li S, Li T, Liu N, Tang F, Gu J, Zhang L, Zhang Z, Zhang X, Jin Y, Le W.Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. Oncotarget. 2017 Jan 31;8(5):7900-7913


Guo F, He XB, Li S, Le W.A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy. Mol Neurobiol. 2016 Nov 10.


Le W, Wu J, Tang Y.Protective Microglia and Their Regulation in Parkinson's Disease. Front Mol Neurosci. 2016 Sep 21;9:89.


Li S, Dong J, Cheng C, Le W.Therapies for Parkinson's diseases: alternatives to current pharmacological interventions. J Neural Transm (Vienna). 2016 Nov;123(11):1279-1299.


Cui Y, Li T, Yang D, Li S, Le W.miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs. Oncotarget. 2016 Oct 4;7(40):64932-64941


Zheng W, Wei M, Li S, Le W.Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences. Nanomedicine (Lond). 2016 Jun;11(11):1417-30.


Yang J, Li S, He XB, Cheng C, Le W.Induced pluripotent stem cells in Alzheimer's disease: applications for disease modeling and cell-replacement therapy. Mol Neurodegener. 2016 May 17;11(1):39.


Qiu H, Zhong R, Liu H, Zhang F, Li S, Le W.Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer's Disease-Like Pathologies in AβPP(swe)/PS1(ΔE9) Mice. J Alzheimers Dis. 2016;50(3):669-85.


Liu H, Qiu H, Xiao Q, Le W.Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer's Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model. J Alzheimers Dis. 2015;48(4):1019-32.


Le W, Zhang L, Xie W, Li S, Dani JA.Pitx3 deficiency produces decreased dopamine signaling and induces motor deficits in Pitx3(-/-) mice. Neurobiol Aging. 2015 Dec;36(12):3314-20.


Liang P, Le W.Role of autophagy in the pathogenesis of multiple sclerosis. Neurosci Bull. 2015 Aug;31(4):435-44. 


Jia J, Le W.Molecular network of neuronal autophagy in the pathophysiology and treatment of depression. Neurosci Bull. 2015 Aug;31(4):427-34.


Xiao Q, Yang S, Le W.G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system. J Neural Transm (Vienna). 2015 Dec;122(12):1645-57.


Chen S, Zhang XJ, Li LX, Wang Y, Zhong RJ, Le W.Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis. Neurosci Bull. 2015 Aug;31(4):459-68.


Liu H, Qiu H, Yang J, Ni J, Le W.Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b. Alzheimers Dement. 2016 Feb;12(2):130-43.


Zhang S, Xiao Q, Le W.Olfactory dysfunction and neurotransmitter disturbance in olfactory bulb of transgenic mice expressing human A53T mutant α-synuclein. PLoS One. 2015 Mar 23;10(3):e0119928.


Tang Y, Le W.Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases. Mol Neurobiol. 2016 Mar;53(2):1181-94.


Yu Z, Wang T, Xu J, Wang W, Wang G, Chen C, Zheng L, Pan L, Gong D, Li X, Qu H, Li F, Zhang B, Le W, Han F.Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease. J Hum Genet. 2015 Feb;60(2):85-90.


Yang J, Tang Y, Liu H, Guo F, Ni J, Le W.Suppression of histone deacetylation promotes the differentiation of human pluripotent stem cells towards neural progenitor cells. BMC Biol. 2014 Nov 19;12:95.


Li T, Yang D, Li J, Tang Y, Yang J, Le W.Critical role of Tet3 in neural progenitor cell maintenance and terminal differentiation. Mol Neurobiol. 2015 Feb;51(1):142-54.


Yang D, Li T, Xu M, Gao F, Yang J, Yang Z, Le W.Graphene oxide promotes the differentiation of mouse embryonic stem cells to dopamine neurons. Nanomedicine (Lond). 2014 Nov;9(16):2445-55.


Zhang X, Chen S, Song L, Tang Y, Shen Y, Jia L, Le W.MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy. 2014 Apr;10(4):588-602.


Tang Y, Li T, Li J, Yang J, Liu H, Zhang XJ, Le W (2014) Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease. Cell Death Differ. 21(3):369-80.


Le W, Sayana P, Jankovic J. (2014) Animal Models of Parkinson’s Disease: A Gateway to Therapeutics? Neurotherapeutics(2014) 11:92–110


Wang Z, Zhang XJ, Li T, Li J, Tang Y, Le W (2014) Valproic Acid Reduces Neuritic Plaque Formation and Improves Learning Deficits in APPSwe /PS1A246E Transgenic Mice via Preventing the Prenatal Hypoxia-Induced Down-Regulation of Neprilysin.CNS Neurosci Ther. 20(3):209-17.


Xiao Q, Chen S, Le W (2014) Hyposmia: a possible biomarker of Parkinson’s disease. Neurosci Bull. 30(1):134-40.


Li J, Li T, Zhang XJ, Tang Y, Yang J, Le W (2013) Human superoxide dismutase 1 overexpression in motor neurons of Caenorhabditis elegans causes axon guidance defect and neurodegeneration. Neurobiol. Aging. 35(4):837-46.


Li J, Le W (2013) Modeling neurodegenerative diseases in Caenorhabditis elegans. Exp. Neurol. 250:94-103.


Chen S, Sayana P, Zhang XJ, Le W (2013) Genetics of amyotrophic lateral sclerosis: an update. Mol Neurodegener. 8:28.


Chen S, Luo GR, Li T, Liu TX, Le W (2013) Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain.J Mol. Neurosci. 51(3):719-23.


Li J, Pu P, Le W (2013) The SAX-3 receptor stimulates axon outgrowth and the signal sequence and transmembrane domain are critical for SAX-3 membrane localization in the PDE neuron of C. elegans. Plos One. 8(6):e65658.


Song L, Gao Y, Zhang XJ, Le W (2013) Galactooligosaccharide improves the animal survival and alleviates motor neuron death in SOD1G93A mouse model of amyotrophic lateral sclerosis. Neuroscience. 29(246):281-290.


Le W, Qin ZH. (2013) New horizon in autophagy research. Acta Pharmacol Sin. 34(5):583-584.


Shen YF, Tang Y, Zhang XJ, Huang KX, Le W (2013) Adaptive changes in autophagy after UPS impairment in Parkinson’s disease. Acta Pharmacol Sin. 34(5):667-673.


Li L, Zhang S, Zhang X, Li T, Tang Y, Liu H, Yang W, Le W (2013) Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer’s Disease. Curr Alzheimer Res. 10(4):433-441.


Zhang X, Li L, Zhang X, Xie W, Li L, Yang D, Heng X, Du Y, Doody RS, Le W (2013) Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer’s disease neuropathology in APP(Swe)/PS1(A246E) transgenic mice. Neurobiol Aging. 34(3):663-78.


Kansara S, Trivedi A, Chen S, Jankovic J, Le W (2013) Early diagnosis and therapy of Parkinson’s disease: can disease progression be curbed? J Neural Transm. 120(1):197-210.


Liu H, Tao Q, Deng H, Ming M, Ding Y, Xu P, Chen S, Song Z, Le W (2013) Genetic analysis of NR4A2 gene in a large population of Han Chinese patients with Parkinson’s disease. Eur J Neurol. 20(3):584-7.


Du Y, Zhang X, Tao Q, Chen S, Le W (2013) Adeno-Associated Virus Type 2 Vector-Mediated Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Induces Neuroprotection and Neuroregeneration in a Ubiquitin-Proteasome System Impairment Animal Model of Parkinson’s Disease. Neurodegener Dis. 11(3):113-28.


Liu H, Wei L, Tao Q, Deng H, Ming M, Xu P, Le W (2012) Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson’s disease. Eur J Neurol. 19(6):870-5.


Yang D, Li T, Wang Y, Tang Y, Cui H, Tang Y, Zhang X, Chen D, Shen N, Le W (2012) miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression. J Cell Sci. 125(Pt 7):1673-82.


Heng X, Jin G, Zhang X, Yang D, Zhu M, Fu S, Li X, Le W (2012) Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons. Mol Neurodegener. 7:4.


Heng X, Breer H, Zhang X, Tang Y, Li J, Zhang S, Le W (2012) Sall3 correlates with the expression of TH in mouse olfactory bulb.J Mol Neurosci. 46(2):293-302.


Wang Y, Yang D, Song L, Li T, Yang J, Zhang X, Le W (2012) Mifepristone inducible caspase-1 expression in mouse embryonic stem cells eliminates tumor formation but spares differentiated cells in vitro and in vivo. Stem Cells. 30(2): 169-79.


Yang DH, Li T, Wang Y, Yang J, Cui HJ, Tang Y, Zhang XJ, Chen DG, Shen N, Le W (2012) miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression. J Cell Sci. 125(Pt 7):1673-82.


Heng X, Jin G, Zhang X, Yang DH, Zhu MZ, Fu SJ, Li XP, Le W (2012) Nurr1 regulates Top IIbeta and functions in axon genesis of mesencephalic dopaminergic neurons. Mol Neurodegener. 7(1):4.


Chen S, Zhang XJ, Song L, Le W (2012) Autophagic dysregulation in amyotrophic lateral sclerosis. Brain Pathology. 22:110-116.


Heng X, Breer H, Zhang X, Tang Y, Li J, Zhang S, Le W (2012) Sall3 Correlates with the Expression of TH in Mouse Olfactory Bulb. J Mol Neurosci. 46(2):293-302.


Peng CG, Aron L, Klein R, Li M, Wurst W, Prakash N, Le W (2011) Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. J Neurosci. 31(36):12802-12815.


Tao QQ, Fan X, Li T, Tang Y, Yang D, Le W (2011) Gender segregation in gene expression and vulnerability to oxidative stress induced injury in ventral mesencephalic cultures of dopamine neurons. J Neurosci. Res. 90(1):167-78.


邀请函

下载邀请函
报名参会
大会咨询
姓名 *

E-mail*

电话: *

消息: *

×
留下姓名电话和邮箱,邀请函直接发送到邮箱
*姓名:
* 电话:
* Email: